Wednesday, December 5, 2007

Autobiography and Goals



'My biggest fear was that when you're writing about yourself, you're writing about yourself. It could come off like an ego trip!' 


- Steve Martin

'The fear of self-promotion consists of all behavioral habits, thoughts, actions, or feelings, which conspire to keep competent people of all walks of life from being able to stand up and take credit for who they are and what they do well!"

- Behavioral scientist George W. Dudley, co-author of the book "Are You Earning What You Are Worth?"

"The ideal scientist thinks like a poet, works like a bookkeeper, and … writes like a journalist."

- E. O. Wilson

Growing up, my interests were heavily affected by family members and acquaintances, many of them were physicians or scientists and instilled in me a love of biology and the living sciences. Through the advice or life examples of these early mentors, I was inspired to prioritise learning and research as my primary life goals.

After completing my public school education, I entered as an undergraduate student at the American College (a "fancy college"), Madurai (affiliated with the Madurai Kamaraj University, Madurai, India) in 1981 and later completed my master's programme there in 1988-90. My studies were halted between 1984 and 1988 because I needed to support my family. I moved on to work as a medical representative and a sales officer for two big pharmaceutical firms (Aristo and Cipla).

I wasn't exactly a rising academic star. If I were to quote Einstein (‘I am not exceptionally clever, only incurably inquisitive,'), I believe that the best scientists were defined by this single most attitude. These were attributes I believed I possessed and which motivated me throughout my scientific career.

Following the completion of my master's degree, I developed an interest in the subject of sleep medicine, which I attribute to my previous experience working in sleep laboratories, as well as the possibility to do sleep-related research. Finally, the science of sleep became a topic close to my heart, and I decided to devote the remainder of my life to researching it. In graduate courses in sleep and chronobiology that I took at the University of Toronto and elsewhere, I was also fortunate to have had talented and motivating lecturers. These experiences have shaped me, and as a result, I am excited to continue my work in sleep research.

There have been various academic and research opportunities since the 1990s that have allowed me to further clarify my interests and research aims. During my master's programme at the University of Toronto, I was particularly interested in sleep and chronobiology. As a postgraduate research student, I worked with Colin M Shapiro, B.Sc., MBBCH., PhD., MRCPSYCH, FRCP(C), of the University of Toronto's Department of Psychiatry, who recommended that I work in clinical areas of sleep medicine in his sleep research laboratory at Toronto Western Hospital. During that time, I worked closely with Leonid Kayumov, Ph.D., RPsgT, ABSM (Kayumov et al., 2000a, b). This experience taught me the fundamentals of clinical sleep medicine, such as how to interact with patients and research subjects, as well as the most technical requirements of scoring and interpreting polysomnographic recordings, diagnosing sleep diseases, and producing reports. Working with Prof. Shapiro and his really multinational research team was a pleasure.

I also worked with Martin R. Ralph, Ph.D., at the University of Toronto's Department of Psychology during this time. During my graduate studies at the university's Institute of Medical Sciences, Prof. Ralph introduced me to several areas of biological rhythms (Pandi-Perumal et al., 2002).

Later, I joined Mircea M. Steriade, MD, DSc, Director of the Laboratory of Neurophysiology at the University of Laval School of Medicine in Quebec, and continued to work on neurophysiological studies of behavioural state control in an animal model utilizing cats. This experience enabled me to work on fundamental sleep-related problems at the molecular and cellular levels. I took part in studies on the involvement of Cortical Ih in the formation of paroxysmal activities, as well as the role of greater association propensity vs. primary visual cortices in the genesis of slow sleep oscillations (Pandi-Perumal et al., 1999; 2000).

I was also fortunate to work with world-renowned researchers such as Michael H. Chase, Ph.D., Department of Physiology and Brain Research Institute (1999-2000), UCLA School of Medicine, and Rosalind D. Cartwright, Ph.D., Department of Psychology, RUSH University Medical Center, Chicago, USA. In collaboration with Prof. Chase, I investigated the intracellular changes in excitability in hypoglossal motoneurons during naturally occurring active sleep (Fung et al., 2001a,b). My involvement with Prof. Cartwright included participation in N.I.M.H.-sponsored sleep research in untreated depressed people (Cartwright et al., 2003). In addition to my solid training, one key reason for my academic achievement was surely the interaction between me and my stimulating mentors, who provided an exciting scientific atmosphere, which was the start of a life-long scientific collaboration. Their connection lasted, and I kept in touch with many of the scientists he met throughout his life. My network continued to expand. I am known for the zeal that drove these fruitful collaborations, for the joy I derived and gave from the successes of others, and for my generosity of spirit.

The national and worldwide research communities played an important role in my social life because I was always in contact with them for various reasons. In my personal life, however, I was very close to my family and spent a lot of time with them. My house served as both a castle and a haven for me.

Concurrent with my clinical and laboratory research activities, I began working as a scientific editor for Landes Bioscience and Springer Verlag in the United States (2003 to present), an experience that has greatly broadened my understanding of the strategy for documenting and presenting findings.

Having connected with several leading academic publishers, I had the opportunity to edit over 25 volumes, and I have published over 300 scientific papers dealing with sleep medicine and chronobiology, and I made many good acquaintances among scientists working in the disciplines of sleep and biological rhythms area all over the world. As a regular or ad hoc reviewer for the journals, I've also had the opportunity to assess and assist journal articles published by notable scientists.

Over the years, I have edited several volumes related to sleep and biological rhythms. This includes, Melatonin: Biological Basis of its Function in Health and Disease (Landes Bioscience, USA, 2005); Neuroendocrine Correlates of Sleep/wakefulness (Springer-Verlag, USA, 2005); Sleep and Sleep Disorders: a Neuropsychopharmacological approach (Landes Bioscience/Eurekha.com and Springer SBM, USA, 2006); Clinical Pharmacology of Sleep (Birkhauser-Verlag, Switzerland, 2006); Sleep disorders: their impact on public health (Informa Healthcare, UK, 2006 - British Medical Association 2007 Award Winner, highly commended - Category Neurology); Neuroimmunology of sleep (Springer-Verlag, USA, 2007); Neurochemistry of Sleep and Wakefulness (Cambridge University Press, England, 2007); Melatonin: from molecules to therapy (NovaScience Publishers, New York, USA, 2007); Primary Care Sleep Medicine: a practical guide (Current Clinical Practice; endorsed by American College of Chest Physicians (ACCP) (Humana Press/Springer-Verlag, USA, 2007); Sleep and Psychosomatic Medicine (Informa Healthcare, UK, 2007); Serotonin and sleep: molecular, functional, and clinical aspects, functions, and regulation (Birkhauser-Verlag, Switzerland, 2007); Sleep and Quality of life in Clinical Medicine, (Humana/Springer, USA, 2008); Experimental Endocrinology and Reproductive Biology (Science Publishers, NH USA, 2007); Sleep Disorders: Diagnosis and Therapeutics (Informa Healthcare, UK, 2008); Principles and Practice of Geriatric Sleep Medicine (Cambridge University Press, UK, 2009); Seasonal Affective Disorder: Practice and Research - 2nd edition, 2009 (Oxford University Press, Oxford, UK), Sleep and Mental Illness (Cambridge University Press, 2009), Drugs, Driving and Traffic Safety (Birkhauser-Verlag, Switzerland), GABA and sleep: Molecular, Functional, and Clinical Aspects (Birkhauser-Verlag, Switzerland, 2010), Rapid Eye Movement Sleep: Regulation and Function (Cambridge University Press, England, 2011, Narcolepsy: a clinical guide (Humana Press/Springer, USA, 2010), Primary Care Sleep Medicine: a practical guide, 2nd edition (Humana Press/Springer, USA, 2014), Narcolepsy: a clinical guide, 2nd edition (Humana Press/Springer, USA, 2010), Sleep and Psychosomatic Medicine, 2nd edition (CRC Press/Informa Healthcare, USA), Orexin and Sleep: molecular, functional, and clinical aspects (Birkhauser-Verlag, Switzerland/Springer USA), Synopsis of Sleep Medicine (Apple Academic Press, Canada) and Dopamine and Sleep: molecular, functional, and clinical aspects (Birkhauser-Verlag, Switzerland/Springer USA); Clinical Atlast of Polysomnography (Apple Academic Press, Canada); Melanin-concentrating hormone and sleep: molecular, functional, and clinical aspects (Springer-Verlag, Switzerland); Sleep and Neuropsychiatry (Springer); Cannabinoids and Sleep: molecular, functional, and clinical aspects (Springer-Verlag, Switzerland); Cannabinoids and neuropsychiatric disorders (Springer-Verlag, Switzerland); Insomnia disorder: Prevalence, causes and current therapeutics (Elsevier, USA) and Sleep and Environments (Elsevier, USA). Editing a volume is not easy. In a job like this even when it is finished, there is always one more thing' to do! 

Book reviews for the aforementioned volumes have appeared in a number of foreign periodicals. This includes, but is not limited to, NEJM, JAMA, American Journal of Psychiatry, Sleep, Sleep Medicine, Clinical Neuropsychiatry, Acta Neuropsychiatrica, Human Psychopharmacology: Clinical and Experimental, Psychological Medicine, Australian, and New Zealand Journal of Public Health, European Journal of Neurology, Comprehensive Therapy, Respiratory Care, Integrative and Comparative Biology, Mayo Clinical Proceedings, Traffic Injury Prevention, The ICADTS (The newsletter of the International Council on Alcohol, Drugs and Traffic Safety) Reporter, and other health-related journals that can be searched online.

I've learned and developed a rudimentary awareness of significant challenges in the world of book publishing throughout the years. As an editor, I was involved in the creation of a number of high-profile volumes in the field of sleep medicine. I learned about several areas of scientific editing and publication in general. For example, I was in charge of various parts of the publishing of the volumes in which I was involved. I helped to organise the submission of incoming chapters, the editorial review production process, and the eventual publication of the volumes. I was able to efficiently communicate with co-editors, contributors, departments, and other administrative employees, as well as monitor the work of subcontractors as necessary. As an editor and/or author (or co-author), I have exhibited abilities and experience with the review process and have been able to perform the entire peer-review process independently and without direct outside supervision. I have professional and academic expertise in all of these areas, including making a sound scientific judgment, (ii) adherence to both current and emerging norms for ethical peer review, (iii) fluent communications abilities, and (iv) the capacity to work with precise deadlines.

Having spent decades in academia, I am now seeking to reach a larger audience with the release of two of my children's books: The titles of the books are 'Alice is sleeping,' which will be published in English (publisher to be determined), and 'Alice and the Sleeping Fairy,' which will be published in Japanese (publisher to be decided). With the release of my first children's book, I hope to raise awareness about how sleep and health are intertwined. This book is the result of that dream. This inventive narrative, titled 'Alice is Sleeping,' is best suited for children aged 4 to 8. The goal of this picture book is to show how advocating a simple idea, such as the critical need for adequate sleep in children, can not only improve the child's medical and mental health but also lead to better adult (healthy sleep) habits. In turn, such a positive way of life can help to transform the world.

In summary, my interest in sleep research stemmed from my interest in biology, but it became more focused as I gained knowledge in classical biology through five years of degree programmes and, more importantly, as I gained experience with the actual process of conducting research. The opportunities I've had to work with some exceptionally accomplished mentors in the field of sleep medicine, in particular, have aided my development significantly. Taken as a whole, I feel my background will allow me to make a substantial contribution to the scientific area.


Research and Professional Experience

2013-2014 Department of Population Health, Center for Healthful Behavior Change, 227 East 30th Street, Between 2nd and 3rd street, New York, NY 10016, USA.

2008-2008 Canadian Sleep Institute, 1 Codsell Ave, Toronto ON M3H 3V6, CANADA.

2005-2007 Sleep Coordinator, Comprehensive Center for Sleep Medicine, Department of Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai School of Medicine, New York, USA.

2003-04 Technical Director and Sleep Disorders Specialist - SL3, Center for Sleep Disorders, Section of Sleep Medicine, Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, State University of New York - Downstate Medical Center (SUNY-DMC), 450 Clarkson Avenue, Box # 1213, Brooklyn, New York, USA.

2002-03 Research Assistant II, Department of Psychology, Sleep Disorder Service and Research Center, RUSH- Presbyterian- St. Luke’s Medical Center, RUSH University, Chicago, IL 60612-3833, USA.

2000-02 Staff Research Associate, Department of Physiology, UCLA School of Medicine, University of California Los Angeles, CA90095, USA.

2000-00 Polysomnography Technologist, Centre for Sleep Disorders, 720 Sheppard Ave, Suite # 7, Pickering, Ontario, ON L1V 1G5 (per diem)

1999-00 Graduate Research Assistant, Laboratory of Neurophysiology, Department of Anatomy and Physiology, University of Laval School of Medicine, Quebec G1K 7P4, Canada.

1996-98 Sleep Researcher, Sleep Research Laboratory, University Health Network, Toronto Hospital - Western Division, Pavilion 6-108, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada.

1990-91 Research Technician, Department of Molecular Microbiology, School of Biotechnology, Madurai Kamaraj University, Madurai-625021, Tamil Nadu, India

Editor-in-Chief

Sleep and Vigilance
Progress in Sleep Research

Associate Editor

Chronobiology in Medicine

Editor - Special Issue

The Neuropsychiatry of Dreaming: Brain Mechanisms and Clinical Presentations

Editor:

Ad hoc External Reviewer

Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
Progress in Neuropsychopharmacology and Biological Psychiatry
The International Journal of Neuropsychopharmacology
Human Psychopharmacology: Clinical and Experimental
CNS & Neurological Disorders - Drug Targets
The European Journal of Pharmacology
American Journal of Medical Genetics
International Journal of Endocrinology
Expert Reviews on Neurotherapeutics
Journal of Psychosomatic Research
Journal of Post Graduate Medicine
Journal of Psychopharmacology
Journal of Affective Disorders
Journal of Circadian Rhythms
Experimental Brain Research
Experimental Dermatology
Journal of Neurochemistry
Sleep Medicine Reviews
European Psychiatry
Psychiatry Research
Sleep and Vigilance
Current Psychiatry
Future Neurology
Injury Prevention
Molecular Vision
Sleep Disorders
Sleep Medicine
Brain Research
Phytochemistry
Cancer Letters
Sleep Science
Critical Care
PLOS One
Biofactors
Drugs
JAMA


RESEARCH ADVISORY COMMITTEE MEMBER



AWARDS

Rakuten Kobo AwardA Vow Owed (selected as one of the shortlisted finalists for the 2019 Emerging Writer Prize for fiction titles)

Inspire Awards 2020-2021 - Most Inspiring Scientist by Ace International Pte Ltd., Singapore.

PICTURE BOOKS FOR CHILDREN

Alice is Sleeping

FICTION

A Vow Owed (selected as one of the shortlisted finalists for the 2019 Emerging Writer Prize for fiction titles from Rakuten Kobo Award)


NEWS PAPER ARTICLE

Pandi-Perumal SR (2021) India’s COVID-19 emergency, geopolitics, and healthcare policy. Goa Chronicle (Status: published)


BOOK REVIEWS

The Sleep Solution: Secrets for a Good Night's Sleep paperback Edition by Manvir Bhatia (Author); Publisher: Penguin/Ebury Press (November 15, 2016), Paperback: 224 pages, ISBN-10: 818400687X; ISBN-13: 978-8184006872.

Why We Sleep: The New Science of Sleep and Dreams by Matthew Walker, Ph.D., Scriber, an imprint of Simon & Schuster, Inc. New York, USA, 368 pages. 2017. ISBN-10: 0241269067; ISBN-13: 978-0241269060.

RECENT PUBLICATIONS:

Pandi-Perumal SR, Spence DW, Leick G, Szpakowska K, Kunow MA, BaHammam AS, Idel M, Askenasy J, Oberhelman S, Mohan Kumar V. (2021) In search of the cradle of sleep and dreams in ancient civilizations. (Status: to be submitted).

Brown GM, Pandi-Perumal SR, BaHammam AS, Spence DW, Monti JM, Hardeland R, Cardinali DP. (2021) Therapeutic implications of melatonin and its synthetic analogs in circadian rhythm sleep disorders, insomnia, and psychiatric disorders. (Status: to be submitted)

Berlim M, Chachamovich E, Jollant F, Spence DW, Pandi-Perumal SR, Turecki G (2021) Predictive validity of sleep disturbance in Treatment-Resistant Depression (TRD): the role of insomnia severity and subtypes. (Status: to be submitted)

Pandi-Perumal SR, et al. (2021) Ethnosomnology: aspects of inequities and inequalities. (Status: to be submitted)

Lundmark PO, Maurya RP, Subramanian P, Tripathi R, Chandra D, Pandi-Perumal SR, Cardinali DP, Brown GM. (2021) Melatonin, Sleep, and Visual dysfunctions (Status: to be submitted)

Asefy Z, Hoseinnejhad S, Ceferov Z, Hasanzadeh A, Eftekhari A, Pandi-Perumal SR, Cardinali DP. (2021) Melatonin as a protective hormone in neurodegenerative diseases: Alzheimer’s and Parkinson’s disease. (Status: to be submitted)

Pandi-Perumal SR, BaHammam AS, Buttoo K, Spence DW, Suchecki D, Cizza G. (2021) Sleep quality and allostatic load among racial and ethnic minorities: Implications for neuroplasticity and disease development. (Status: to be submitted)

Soni SK, Basu P, Singaravel M, Pandi-Perumal SR, Cardinali DP. (2021) Melatonin: a safeguard against chronodisruption. (Status: to be submitted)

Karthikeyan R, Gupta R, Spence DW, BaHammam AS, Pandi-Perumal SR, Cardinali DP, Brown GM (2021) The neurobiology of bipolar disorder. (Status: to be submitted)

Karthikeyan R, Marimuthu G, Spence DW, BaHammam AS, Pandi-Perumal SR, Cardinali DP, Brown GM. (2021) Clock genes and Schizophrenia. (Status: to be submitted)

Arumugam M, Pandi-Perumal SR, Subramanian P. (2020) Regulation of circadian clock proteins, inflammatory and apoptotic markers under rotenone-induced oxidative stress in Drosophila melanogaster: influence of hesperidin. (Status: to be submitted) 

Pandi-Perumal SR, Spence DW, Mallick BN, García-García F, Tortorolo P, Monti J (2021) Why do we sleep? deciphering the fundamental need for sleep (Status: to be submitted)

Azharuddin M, Aldabbas M, Aseem A, Pandi-Perumal SR, Veqar Z. Influence of concurrent exercise and its timing on polysomnographic parameters and subjective sleep quality in adults with poor sleep. (Status: to be submitted).

Ram K, Kawamura K, Singh DK, Lepcha A, Maurya RP, BaHammam AS, Pandi-Perumal SR. Exposure dose estimation for airborne transmission and infection mechanisms in COVID-19: A review from aerosol science perspectives. (Status: to be submitted).

Rai S, Hajam YA, Bhaskar LVKS, Spence DW, Pandi-Perumal SR, Brown GM, Reiter RJ, Cardinali DP. Nutritional Choices: A Major Initiator of Metabolic Disorder. (Status: to be submitted).

Venkatesan A, Natesan V, Rajendran J, Pandi-Perumal SR, Bharti VK, Tripathi YC. A review of COVID-19 and Diabetes: Pathology, Complication and Clinical Management. (Status: to be submitted).

Chattu VK, Sunil TS, Santaji S, Desai VV, Garg L, Nurtazina A, Allahverdipour H, Pandi-Perumal SR. Precision Medicine meets Sleep Medicine: how sleep health can avert the avoidable burden of Non-communicable diseases? Sleep Vigil. (Status: submitted)

Burman D, Manzar MD, Chattu VK, Spence DW, Chattu SK, Anderson R, Gupta R, Pandi-Perumal SR. Sleep and its association with Autism Spectrum Disorder. (Status: to be submitted).

Gupta R, Karthikeyan R, Cardinali DP, Brown GM, BaHammam AS, Pandi-Perumal SR. (2021) Sleep of children: why do they need attention? (Status: to be submitted)

Elsayed  S, Rizk YMS, Zaki NFW, Elnagar EA, Spence DW, Pandi-Perumal SR (2020) A study of personality disorders among adult suicide attempters. (Status: to be submitted).

Ghosh H, Rai S, Pandi-Perumal SR, Brown GM, Reiter RM, Cardinali DP (2021) Differential expression and interaction of melatonin (MT1/ MT2) and thyroid (TRa / Dio2) receptors with ERa improves ovarian function in letrozole induced polycystic (PCO) rats. (Status: to be submitted)

Pandi-Perumal SR, Srivastava N, Kanchibhotla D, Spence DW, Kumar K, Sharma GS, Gupta R, Batmanabane G (2021) Yoga Nidra and its utility in clinical medicine. Sleep Vigil. (Status: Under revision)

Jahrami H, Alhaj O, Humood A, Alenezi A, Fekih-Romdhane F, AlRasheed M, Saif Z, NBragazzi NL, Pandi-Perumal SR, BaHammam AS, Vitiello MV. Sleep problems during the COVID-19 pandemic: a systematic review, meta-analysis, and metaregression. Sleep Med Rev. (Status: submitted)

Rai S, Hajam YA, Bhaskar LVKS, Spence DW, Pandi-Perumal SR, Brown GM, Cardinali DP. (2021) Nutritional Choices: A Major Initiator of Metabolic Disorder. Current Pharmaceutical Design (Status: submitted)

Gupta R, Burman D, BaHammam AS, Kendzerska T, Ebben MR, Buttoo K, Manzar MD, Neubauer DN, Pandi-Perumal SR (2021) The relationship between insomnia and depression: a new twist to an old story of common bedfellows (Status: to be submitted)

Jehan S, Zizi F, Pandi-Perumal SR, McFarlane SI, Jean-Louis G, Myers AK (2021) Metabolic Syndrome: Etiology and Outcomes. (Status: to be submitted)

Brown GM, Pandi-Perumal SR, Pupko H, Kennedy JL, Dubocovich ML, Cardinali DP. Melatonin as add-on treatment of Covid-19 infection: current status. (Status: to be submitted)

Azharuddin M, Aldabbas M, Aseem A, Tanwar T,  Iram I, Pandi-Perumal SR, Zubia Veqar Z. Influence of concurrent exercise and its timing on polysomnographic parameters and subjective sleep quality in collegiate adults with poor sleep. (Status: to be submitted)

Shoib S, Malik JA, Ullah I, Pandi-Perumal SR. (2021) The Effect of Continuous Positive Airway Pressure on Depressive Symptoms in Obstructive Sleep Apnea. (Status: to be submitted). 

Cardinali DP, Brown GM, Pandi-Perumal SR (2021) A claim for the use of melatonin in the COVID-19 pandemic. (Status: submitted)

Veqar Z, Aldabbas M, Tanwar T, Iram I. Spence DW, Pandi-Perumal SR (2021) Sleep Disturbance in Neck Pain Patients: Implications to Pain Intensity and Disability. Sleep and Hypnosis (Status: Submitted)

Chattu VK, Santaji S, Nargundkar S, Desai VV, Garg L, Sunil TS, Pandi-Perumal SR. Role of artificial intelligence in achieving "triple billion" targets in global health. Healthcare (Status: Submitted)

Pandi-Perumal SR, Alhejaili F, AlQassas IA, Manzar MD, Al-Jahdali HH, Jahrami HA, BaHammam AS, Wali SO. Sleep, circadian dysregulation, and fatigue among pilots. (Status: to be submitted) 

Pandi-Perumal SR, Zaki NFW, Karthikeyan R, Spence DW, Cardinali DP, Brown GM (2021) Timing is everything: what it has to do with sleep? Front Neuroendocrinol. (Status: Under revision).

Chattu VK, Thankam S. Sunil TS, Santaji S, Desai VV, Nurtazina A, Pandi-Perumal SR (2021) Precision Medicine meets Sleep Medicine: how sleep health can avert the avoidable burden of Non-communicable diseases. Sleep Vigil. (Status: Revision submitted)

Hajam YA, Seema Rai S, Pandi-Perumal SR, Brown GM, Reiter RJ, Cardinali DP. Co-administration of melatonin and insulin improves diabetic-induced impairment of rat kidney function. (Status: submitted)

Ghrouz AK, Noohu M, Manzar MD, Bekele BB, Pandi-Perumal SR, Bahammam AS. (2021) Short-term insomnia symptoms are associated with level and not type of physical activity in a sample of Indian collegiate students: Sleep complaints and physical activity in college students. J Prev Med Hyg. (Status: Accepted)

Manzar MD, Mohammed S, Alghadir A, Anwer S, Sony P, Bahammam AS, Pandi-Perumal SR. (2021) Psychometric properties of the Generalized Anxiety Disorder-7 Scale in Ethiopian university students. Bulletin of the Menninger Clinic (Status: Accepted)

Mohammed S, Manzar MD, Bahammam AS, Pandi-Perumal SR. (2021) Emerging challenges in COVID-19 with Substance use disorders. Addictive Disorders & Their Treatment (Status: Accepted)

Zaki NFW, Siddiq M, Qasim M, Aranas B, Hakamy A, Ruwais NA, Alanezi H, Al Saudi DAA, AlShahrani RBS, Al-Thomali ABA, Manzar MD, BaHammam AS, Al-Kaabba AF, Pandi-Perumal SR. (2021) Stress and Psychological Consequences of COVID -19 on Healthcare Workers. Nature Sci Med. (Status: Accepted)

Kumar VM, Pandi-Perumal SR. Why Indian Scientific Contributions do not Fetch Nobel Prize. Sleep Vigil. (Status: accepted) 

Kumar VM, Pandi-Perumal SR, Gupta DK. Are the Medical Journals Justified in Criticizing India’s COVID-19 Management Policy? Ann Natl Acad Med Sci. (India) 57(3):1-4; DOI: 10.1055/s-0041-1735757.

Mohammed S, Manzar MD, Unissa A, Pandi-Perumal SR, Bahammam AS. The global shortage of essential drugs during the COVID-19 pandemic: evidence based on aggregated media and social media reports. J Nature Sci Med. Medicine 4(4) (Status: Accepted)

Brown GM, Pandi-Perumal SR, Pupko H, Kennedy JL, Cardinali DP. Melatonin as an Add-On Treatment of COVID-19 Infection: Current Status. Diseases. 2021 Sep 20;9(3):64. doi: 10.3390/diseases9030064.

Kinyoki D, Osgood-Zimmerman AE, Bhattacharjee NV, Local Burden of Disease Anaemia Collaborators; Kassebaum NJ, Hay SI. Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018. Nat Med. 2021 Oct;27(10):1761-1782. doi: 10.1038/s41591-021-01498-0.

Jean-Louis G, Grandner MA, Pandi-Perumal SR. Sleep Health and Longevity—Considerations for Personalizing Existing Recommendations. JAMA Network Open. 2021;4(9):e2124387. doi:10.1001/jamanetworkopen.2021.24387. [Invited commentary]


Bhattacharjee NV, Schaeffer LE, Hay SI; Local Burden of Disease Exclusive Breastfeeding Collaborators. Mapping inequalities in exclusive breastfeeding in low- and middle-income countries, 2000-2018. Nat Hum Behav. 2021 Aug;5(8):1027-1045. doi: 10.1038/s41562-021-01108-6. 

Local Burden of Disease HIV Collaborators. Subnational mapping of HIV incidence and mortality among individuals aged 15-49 years in sub-Saharan Africa, 2000-18: a modelling study. Lancet HIV. 2021 Jun;8(6):e363-e375. doi: 10.1016/S2352-3018(21)00051-5.

Pandi-Perumal SR, Vaccarino S, Chattu VK, Zaki NFW, BaHammam AS, Manzar MD, Maestroni GJM, Suchecki D, Moscovitch A, Zizi F, Jean-Louis G, Narasimhan M, Ramasubramanian C, Trakht I, Seeman MV, Shneerson JM, Maes M, Reiter RJ, Kennedy SH. (2021) 'Distant socializing,' not 'social distancing' as a public health strategy for COVID-19. Pathog Glob Health. 2021 May 30;1-8. doi: 10.1080/20477724.2021.1930713. 

Alhejaili F, Hafez A, Wali S, Alshumrani R, Alzehairi AM, Balkhyour M, Pandi-Perumal SR. Prevalence of Obstructive Sleep Apnea Among Saudi Pilots. Nat Sci Sleep. 2021; 13: 537–545. doi: 10.2147/NSS.S299382.

Ravi Gupta R, Pandi‑Perumal SR. SARS‑CoV‑2 Infection: Paving Way for Sleep Disorders in Long Term! Sleep and Vigilance https://doi.org/10.1007/s41782-021-00145-5. [Editorial]

Kumar VM, Pandi-Perumal SR, Trakht I, Thyagarajan SP. (2021) Strategy for COVID-19 Vaccination in India: the country with the second highest population and number of cases. npj Vaccines 6, 60 (2021). https://doi.org/10.1038/s41541-021-00327-2. [Perspective]

Szabadi E, Reading PJ, Pandi-Perumal SR (2021) The Neuropsychiatry of Dreaming: Brain Mechanisms and Clinical Presentations. Front. Neurol. doi: 10.3389/fneur.2021.666657. [Editorial]

Ozkalayci F, Kocabas U, Altun BU, Pandi-Perumal S, Altun A (2021) Relationship Between Melatonin and Cardiovascular Disease. Cureus. 2021 Jan 27;13(1):e12935. doi: 10.7759/cureus.12935.

Pandi-Perumal SR, Santaji S, Desai VV, Sunil T, Chattu VK (2021) The blockchain never sleeps: How can blockchain technology transform sleep medicine? Sleep Vigil. https://doi.org/10.1007/s41782-021-00132-w.

Brown GM, Karthikeyan R, Pandi-Perumal SR, Cardinali DP. (2021) Autism Spectrum Disorder patients may be susceptible to COVID-19 disease due to deficiency in melatonin. Med Hypotheses. 2021 Feb 18;149:110544. doi: 10.1016/j.mehy.2021.110544. 

Nami M, Rao KS, Pandi-Perumal SR, Kateb B. (2021) ‘Love and Fear’ as portraited by Affective Neuroscience. Editorial. JAMSAT (Status: accepted).

Jehan S, Zizi F, Pandi-Perumal SR, McFarlane SI, Jean-Louis G, Myers AK (2021) Obstructive sleep apnea hypertension, resistant hypertension and cardiovascular disease. Sleep Med Dis Int J. 2020;4(3):67-76. DOI: 10.15406/smdij.2020.04.00076. 

Cardinali DP, Brown GM, Pandi-Perumal SR. (2021) An urgent proposal for the immediate use of melatonin as an adjuvant to anti- SARS-CoV-2 vaccination. Melatonin Research. 4, 1 (Jan. 2021), 206-212. https://doi.org/10.32794/mr11250091.

Naeem AA, El-boraie HA, Abou-Elsaad TA, Khater ME, Manzar MD, Spence DW, Pandi-Perumal SR, Zaki NFK (2021) Can sleep profiles predict autistic traits in siblings of children with autism spectrum disorder? Sleep Sci. (Status: Published)

Soni SK, Basu P, Singaravel M, Sharma R, Pandi-Perumal SR, Cardinali DP, Reiter RJ (2021) Sirtuins and the circadian clock interplay in cardioprotection: focus on Sirtuin 1. Cell Mol Life Sci. 2021 Jan 3. doi: 10.1007/s00018-020-03713-6. 

Manzar MD, Salahuddin M, Pandi-Perumal SR, Bahammam AS. (2021) Insomnia May Mediate the Relationship Between Stress and Anxiety: A Cross-Sectional Study in University Students. Nat Sci Sleep. 2021 Jan 8;13:31-38. doi: 10.2147/NSS.S278988. 

Jehan S, Zizi F, Pandi-Perumal SR, McFarlane SI, Jean-Louis G, Myers AK (2020) Obstructive sleep apnea hypertension, resistant hypertension and cardiovascular disease. Sleep Med Dis Int J. 2020;4(3):67-76. DOI: 10.15406/smdij.2020.04.00076. 

Bekele BB, Manzar MD, Alqahtani M, Pandi-Perumal SR. (2020) Diabetes mellitus, metabolic syndrome, and physical activity among Ethiopians: A systematic review. Diabetes Metab Syndr. 2020 Dec 31;15(1):257-265. doi: 10.1016/j.dsx.2020.12.031. 

Gupta R, Pandi-Perumal SR (2020) COVID-Somnia: How the Pandemic Affects Sleep/Wake Regulation and How to Deal with it? Sleep Vigil. 2020 Dec 3:1-3. doi: 10.1007/s41782-020-00118-0. 

Cardinali DP, Brown GM, Pandi-Perumal SR. (2020) Melatonin. A potential "Silver Bullet" in treating COVID-19 patients. Diseases 2020, 8(4), 44; https://doi.org/10.3390/diseases8040044.

Blanc J, Briggs AQ, Seixas AA, Reid M, Jean-Louis G, Pandi-Perumal SR (2021) Addressing psychological resilience during the coronavirus disease 2019 pandemic: a rapid review. Curr Opin Psychiatry. 2021 Jan;34(1):29-35. doi: 10.1097/YCO.0000000000000665.

Pandi-Perumal SR, Maurya RP, Chandra D, Shalini, Singh OP, Tripathi RA, Tripathi YC, Giri A, Bharti VK (2020) Herbal remedies and COVID-19: where is the evidence? Asian J. Pharmacogn. (Status: Accepted).

Jehan S, Zizi F, Pandi-Perumal SR, McFarlane SI, Jean-Louis G, Myers AK. Energy imbalance: obesity, associated comorbidities, prevention, management and public health implications. Adv Obes Weight Manag Control. 2020;10(5):146‒161.

Tanwar T, Veqar Z, Ghrouz AK, Spence DW, Pandi-Perumal SR (2020) Is poor sleep quality associated with a deterioration in postural control? Sleep Science. DOI: 10.5935/1984-0063.20200061.

Pandi-Perumal SR, Cardinali DP, Reiter RJ, Brown GM. (2020) Low melatonin as a contributor to SARS-CoV-2 disease. Melatonin Research  Vol 3 No 4 (2020). DOI: https://doi.org/10.32794/mr11250079.

Wali SO, Abaalkhail B, AlQassas I, Alhejaili F, Spence DW, Pandi-Perumal SR (2019) The correlation between oxygen saturation indices and the standard obstructive sleep apnea severity. Ann Thorac Med. 2020 Apr-Jun; 15(2): 70–75. doi: 10.4103/atm.ATM_215_19.

Pandi-Perumal SR (2020) India's Manned Spaceflight: Incisive Perspectives on the Vigilance of the Crew During the Mission. Sleep Vigil. DOI: 10.1007/s41782-020-00112-6.

Salahuddin M, Manzar MD, Hassen HY, Unissa A, Abdul Hameed U, Spence DW, Pandi-
Population Living with HIV. HIV AIDS (Auckl). 2020 Oct 13;12:559-572. doi:10.2147/HIV.S260831. 

Pandi-Perumal SR, Cardinali DP, Reiter RJ, Brown GM (2020) Low melatonin as a contributor to SARS-CoV-2 disease. Melatonin Research vol 3(4). DOI: https://doi.org/10.32794/mr11250079.

Cardinali DP, Brown GM, Reiter RJ, Pandi-Perumal SR. Elderly as the high-risk group during COVID-19 pandemic: effect of circadian misalignment, sleep dysregulation and melatonin administration. Sleep Vigil. 2020 Sep 26:1-7. doi: 10.1007/s41782-020-00111-7. 

Pandi-Perumal SR. (2020) India’s Manned Spaceflight: Incisive Perspectives on the Vigilance of the Crew During the Mission. Sleep Vigil. [Perspective].

Chattu VK, Jean-Louis G, Pandi-Perumal SR, Zeller JL. (2020) Aiding Universal Health Coverage through Humanitarian Outreach Services and Global Health Diplomacy in Resource-Poor Settings. J Natl Med Assoc. https://doi.org/10.1016/j.jnma.2020.07.015.

Manzar MD, Hameed UA, Alqahtani M, Salahuddin M, Morgan P, Bahammam AS, Pandi‐Perumal SR. (2020) Obstructive sleep apnea screening in young people: Psychometric validation of a shortened version of the STOP‐BANG questionnaire using categorical data methods. Ann Thorac Med. DOI: 10.4103/atm.ATM_389_19. 

Manzar MD, Pandi-Perumal SR, Bahammam AS. (2020) Lockdowns for community containment of COVID-19: Present challenges in the absence of interim guidelines. J Nat Sci Med.  3(4): 318-321. DOI: 10.4103/JNSM.JNSM_68_20. 

Zaki NFW, Sabry YM, Farouk O, Abdelfatah A, BaHammam AS, Pandi-Perumal SR. (2020) Depressive Symptoms, Sleep Profile, and Serum Melatonin Levels in a Sample of Breast Cancer Patients. Nat Sci Sleep. 2020; 12: 135–149. doi: 10.2147/NSS.S206768.

Kamal M, Zaki NFW, Yousef EA, Eltoraby E, Manzar MD, Pandi-Perumal SR. An Egyptian Study of Sleep Disorders and Its Correlates in End-Stage Renal Disease Patients Receiving Hemodialysis. Sleep and Vigilance. https://doi.org/10.1007/s41782-020-00095-4.

Zaki NFW, Karthikeyan R, Spence DW, Subramanian P, Bharti VK, BaHammam AS, Pandi-Perumal SR. (2020) Basic chronobiology: What do sleep physicians need to know? DOI: 10.5935/1984-0063.20200026.

Pandi-Perumal SR, Burman D, BaHammam AS, Karthikeyan R, Gupta R, Cardinali DP, Brown GM, Narasimhan M (2020) Clarifying the role of sleep in depression: A narrative review. Psychiatry Res. 2020 Jun 16;291:113239. doi: 10.1016/j.psychres.2020.113239.

Pandi-Perumal SR, Gulia KK, Gupta D, Mohan Kumar V. Dealing with a pandemic: The Kerala Model of containment strategy for COVID-19. Pathog Glob Health. 2020 Jun 19:1-2. doi: 10.1080/20477724.2020.1778392.

BaHammam AS, Alnakshabandi K, Pandi-Perumal SR (2020) Neuropsychiatric Correlates of Narcolepsy. Curr Psychiatry Rep. 2020 Jun 5;22(8):36. doi: 10.1007/s11920-020-01159-y. 

Manzar MD, Hameed UA, Mohammed S, Khan MYA, Nureye D, Wakene W, Alamri M, Albougami A, PandiPerumal SR, Bahammam AS. (2020) Migraine Screen Questionnaire: Further psychometric evidence from categorical data methods. Health Qual Life Outcomes. 2020 Apr 28;18(1):113. doi: 10.1186/s12955-020-01361-9.

Sirajudeen MS, Manzar MD, Alqahtani M, Alzhrani M, Albougami A, Pillai PS, Spence DW, Pandi-Perumal SR. (2020) Psychometric properties of the Athens Insomnia Scale in occupational computer users. Healthcare (Basel). 2020 Apr 7;8(2):E89. doi: 10.3390/healthcare8020089.

Wali SO, Abaalkhail B, AlQassas I, Alhejaili F, Spence DW, Pandi‑Perumal SR. (2020) The correlation between oxygen saturation indices and the standard obstructive sleep apnea severity. Ann Thorac Med. 2020 Apr-Jun; 15(2): 70–75. doi: 10.4103/atm.ATM_215_19.

Karthikeyan R, Cardinali DP, Shakunthala V, Spence DW, Brown GM, Pandi-Perumal SR. (2020) Understanding the role of sleep and its disturbances in Autism spectrum disorder. Int J Neurosci. 2020 Jan 14:1-14. doi: 10.1080/00207454.2019.1711377.

Chattu V, Chattu SK, Spence DW, Manzar MD, Burman D, Pandi-Perumal SR. (2019) Do disparities in sleep duration among racial and ethnic minorities contribute to differences in disease prevalence?  J Racial Ethn Health Disparities, 6 (6), 1053-1061. DOI: 10.1007/s40615-019-00607-7.

Morsy NE, Badawi AE, Ahmad MA, Awadalla NJ, Pandi-Perumal SR, BaHammam AS, Lundmark PO, Zaki NFW. (2019) Predictors of ocular complications in obstructive sleep apnea patients: a cross-sectional case-control study. The Open Respiratory Medicine Journal 13:19-30. DOI: 10.2174/1874306401913010019. 

Noohu MM, Manzar MD, Bekele BB, Salahuddin M, Albougami A, Spence DW, Pandi-Perumal SR, BaHammam AS. Prevalence of poor sleep quality in the Ethiopian population: A systematic review and meta-analysis. Sleep Breath. doi: 10.1007/s11325-019-01871-x. 

Gupta R, Pandi-Perumal SR. Editorial: Siesta: Still an enigma. Sleep Vigil. 3: 1.

Gupta R, Pandi-Perumal SR (2019) Editorial: “Sleep Well, Sleep on Time” and Insufficient Sleep: A Need for More Research and Public Health Policies. Sleep Vigilance 3, 91–93.

Karthikeyan R, Spence DW, Pandi-Perumal SR. (2019) The contribution of modern 24-hour society to the development of type 2 diabetes: the role of insufficient sleep. Sleep Science (Status: Accepted).

Zaki NFW, Yousif M, BaHammam AS, Spence DW, Bharti VK, Subramanian P, Pandi-Perumal SR (2019) Chronotherapeutics: recognizing the importance of timing factors in the treatment of disease and sleep disorders. Clin Neuropharmacol. DOI: 10.1097/WNF.0000000000000341.

Nesreen E. Morsy NE, Farrag NS, Zaki NFW, Badawy AY, Abdelhafez SA, El-Gilany AH, EL shafey MM, Pandi-Perumal SR, Spence DW, BaHammam AS. (2019) Obstructive sleep apnea: Personal, Societal, Public Health, and Legal Implications. Rev Environ Health. https://doi.org/10.1515/reveh-2018-0068.

Pandi-Perumal SR, Zeller JL, Parthasarathy S, Edward Freeman R, Narasimhan M. (2019) Herding cats and epic challenges: making meaningful stakeholder engagement in clinical research. Asian J Psychiatr. (Status: Accepted)   

Almeneessier AS, BaHammam AA, Olaish AH, Pandi-Perumal SR, Manzar MD, BaHammam AS. (2019) Effects of Diurnal Intermittent Fasting on Daytime Sleepiness reflected by the EEG Absolute Power. J Clin Neurophysiol. 2019 Mar 4. doi: 10.1097/WNP.0000000000000569. 

Chattu VK, Chattu SK, Burman D, Spence DW, Pandi-Perumal SR. (2019) The Interlinked rising Epidemic of Insufficient Sleep and Diabetes Mellitus. Healthcare, 2019, 7(1), 37. 

Manzar MD, Salahuddin M, Alamri M, Albougami A, Khan MYA, Nureye D, Spence DW, Pandi-Perumal SR. (2019) Psychometric properties of the Epworth sleepiness scale in Ethiopian university students. Health and Quality of Life Outcomes (2019) 17:30. https://doi.org/10.1186/s12955-019-1098-9.

Manzar MD, Albougami A, Salahuddin M, Sony P, Spence DW, Pandi-Perumal SR. (2019) The Mizan Meta-memory and meta-concentration Scale for students (MMSS): A test of its psychometric validity in a sample of university students. BMC Psychology (2018) 6:59. https://doi.org/10.1186/s40359-018-0275-7.

Manzar MD, Salahuddin M, Peter S, Alghadir A, Anwer S, Bahammam AS, Pandi-Perumal SR. (2019). Psychometric properties of the perceived stress scale in Ethiopian university students. BMC Public Health. 2019 Jan 9;19(1):41. doi: 10.1186/s12889-018-6310-z. 

Ghrouz AK, Noohu MM, Dilshad Manzar M, Warren Spence D, BaHammam AS, Pandi-Perumal SR. (2019). Physical activity and sleep quality in relation to mental health among college students. Sleep Breath. 2019 Jan 26. doi: 10.1007/s11325-019-01780-z.  

Zaki NFW, Saleh E, Elwasify M, Mahmoud E, Zaki J, Spence DW, BaHammam AS, Pandi-Perumal SR. (2019) The association of BDNF gene polymorphism with cognitive impairment in insomnia patientsProg Neuropsychopharmacol Biol Psychiatry. 2019 Jan 10;88:253-264.

Chattu VK, Manzar MD, Kumary S, Burman D, Spence DW, Pandi-Perumal SR. The Global Problem of Insufficient Sleep and Its Serious Public Health Implications. Healthcare (Basel). 2018 Dec 20;7(1). pii: E1. doi: 10.3390/healthcare7010001.

Manzar MD, Salahuddin M, Alamri M, Khan MAY, Chattu VK, Pandi-Perumal SR, Bahammam AS (2018) Psychometric properties of the Severity of the dependence scale for Khat (SDS-Khat) in polysubstance users. BMC Psychiatry. 2018 Oct 19;18(1):343. doi: 10.1186/s12888-018-1917-2.

Jehan S, Farag M, Zizi F, Pandi-Perumal SR, Chung A, Truong A, Jean-Louis G, Tello D, McFarlane SI. Obstructive sleep apnea and stroke. Sleep Med Disord. 2018;2(5):120-125.

Manzar MD, Albougami A, Mohammed S, Sony P, Spence DW, Pandi-Perumal SR (2018) The Mizan Meta-memory and meta-concentration Scale for students (MMSS): A test of its psychometric validity in a sample of university students. BMC Psychology 6:59.

Almeneessier AS, Pandi-Perumal SR, BaHammam AS. (2018) Intermittent Fasting, Insufficient Sleep, and Circadian Rhythm: Interaction and Effects on the Cardiometabolic System. Curr Sleep Medicine Rep 4: 179.

Wali SO, Abaalkhail B, Alhejaili F, Pandi-Perumal SR. (2018) Efficacy of vitamin D replacement therapy in restless legs syndrome: a randomized control trial. Sleep Breath. https://doi.org/10.1007/s11325-018-1751-2.

Gupta R, Pandi-Perumal SR. (2018) Addictive Substances and Sleep: More Research is Needed. Sleep and Vigilance. https://doi.org/10.1007/s41782-018-0052-y.

Zaki NFW, Elnagar M, Spence DW, Pandi-Perumal SR, Shams M. (2018) The prevalence of female sexual dysfunction (FSD) in women attending a hospital-based infertility clinic: A cross-sectional observational study from  Egypt. The Arab Journal of Psychiatry 29(1): 35-47. doi. 10.12816/0046441.

Manzar MD, Salahuddin M, Khan TA, Shah SA, Alamri M, Pandi-Perumal SR, Bahammam AS. (2018) Psychometric properties of the Insomnia Severity Index in Ethiopian adults with substance use problems. J Ethn Subst Abuse. 2018 Sep 5:1-15. doi: 10.1080/15332640.2018.1494658.

Almeneessier AS, Pandi-Perumal SR, BaHammam AS. (2018) Intermittent fasting, insufficient sleep, and circadian rhythm: Interaction and effects on the cardiometabolic system. Current Sleep Medicine Reports September 2018, Volume 4, Issue 3, pp 179–195.

Jehan S, Myers AK, Zizi F, Pandi-Perumal SR, Jean-Louis G, Singh N, Ray J, McFarlane SI. (2018) Sleep health disparity: the putative role of race, ethnicity and socioeconomic status. Sleep Med Dis Int J. 2018;2(5):127‒133. DOI: 10.15406/smdij.2018.02.00057.

Jehan S, Myers AK , Zizi F, Pandi-Perumal SR, Jean-Louis G, Samy I. McFarlane SI. (2018) Obesity, OSA, and Type 2 Diabetes Mellitus: Epidemiology and Pathophysiologic Insights. Sleep Med Disord. 2018;2(3):52-58.

Manzar MD, SalahuddinM, Alamri M, Maru TT, Pandi-Perumal SR, Bahammam AS. (2018) Poor sleep in concurrent users of alcohol, khat and tobacco smoking in community-dwelling Ethiopian adults. Ann Thorac Med. 2018 Oct-Dec; 13(4): 220–225.

Chattu VK, Kumar R, Sakhamuri SM, Spence DW, BaHammam AS, Pandi-Perumal SR. (2018) Insufficient sleep syndrome: Is it time to recognize it as a major non-communicable disease? Sleep Sci. 2018 Mar-Apr; 11(2): 56–64.

Almenessier AS, Almari BN, Alzahrani FR, Sharif MM, Pandi-Perumal SR, BaHammam AS. (2018) Insomnia in primary care settings: still overlooked and undertreated? J Nat Sci Med. DOI: 10.4103/JNSM.JNSM_30_18

Manzar MD, BaHammam AS, Kumalo A, Hameed UA, Pandi-Perumal SR, Moscovitch A, Streiner DL. (2018) Dimensionality of the Pittsburgh Sleep Quality Index: a systematic review. Health and Quality of Life Outcomes (Status: Published). https://doi.org/10.1186/s12955-018-0915-x.

Pagel JF, Pandi-Perumal SR, Monti JM (2018) Treating insomnia with medications. Sleep Science and Practice (Status: Published). https://doi.org/10.1186/s41606-018-0025-z.

Gupta R, Pandi-Perumal SR. (2018) Sleep, Oh Sleep, Where Art Thou? Sleep and Vigilance June 2018, Volume 2, Issue 1, pp 1–3. https://doi.org/10.1007/s41782-018-0043-z

Özkalaycı F, Gülmez Ö, Uğur-Altun B, Pandi-Perumal SR, Altun A. (2018) The Role of Osteoprotegerin as a Cardioprotective Versus Reactive Inflammatory Marker: the Chicken or the Egg Paradox. Balkan Med J 2018;35:225-232. DOI : 10.4274/balkanmedj.2018.0579.

Neubauer DN, Pandi-Perumal SR, Spence DW, Buttoo K, Monti JM. (2018) Pharmacotherapy of insomnia. Journal of Central Nervous System Disease Volume 10: 1–7

Karthikeyan R , Spence DW, Brown  GM, Pandi-Perumal SR (2018) Are type 2 diabetes mellitus and depression part of a common clock genes network? J Circadian Rhythms (Status: Accepted)

Manzar MD, Salahuddin M, Maru TT, Alghadir A, Anwer S, Bahammam AS, Pandi-Perumal SR. (2018) Validation of the adapted Leeds Sleep Evaluation Questionnaire in Ethiopian university students. Health and Quality of Life Outcomes 16:49.

Zaki NFW, Spence DW, BaHammam AS, Pandi-Perumal SR, Cardinali DP, Brown GM. (2018) Sleep and circadian rhythms in health and disease - a complex interplay. Eur Arch Psychiatry Clin Neurosci. pp.1-2.  https://doi.org/10.1007/s00406-018-0866-6.

Choudhary S, Hussain ME, Moscovitch A, Pandi-Perumal SR, BaHammam AS. (2018) Multimodal physiotherapy improves pain, functional disability, sleep quality and health related quality of life in chronic mechanical neck pain patients. International Journal of Health Sciences & Research (www.ijhsr.org) 8(3):138-148

Salahuddin M, Maru TT, Kumalo A, Pandi-Perumal SR, Bahammam AS, Manzar MD. Validation of the Pittsburgh sleep quality index in community dwelling Ethiopian adults. BMC Health Qual Life Outcomes. 2017; 15: 58. PMCID: PMC5369003, doi:  10.1186/s12955-017-0637-5.

Pandi-Perumal SR, Gupta R. "Nobel" Clock: deeper impact than we originally thought! Sleep and Vigilance, 2017. Editorial. 

Jehan S, Auguste E, Pandi-Perumal SR, Kalinowski J, Myers AK, Zizi F, Rajanna MG, Jean-Louis G, McFarlane SI. Depression, Obstructive Sleep Apnea and Psychosocial Health. Sleep Med Disord. 2017;1(3). pii: 00012.

Jehan S, Zizi F, Pandi-Perumal SR, Wall S, Auguste E, Myers AK, Jean-Louis G, McFarlane SI. Obstructive Sleep Apnea and Obesity: Implications for Public Health. Sleep Med Disord. 2017;1(4). pii: 00019. Epub 2017 Dec 12. PMID: 29517065.

Jehan S, Zizi F, Pandi-Perumal SR, Myers AK, Auguste E, Jean-Louis G, McFarlane SI. Shift Work and Sleep: Medical Implications and Management. Sleep Med Disord. 2017;1(2). pii: 00008. PMID: 29517053.

Jehan S, Jean-Louis G, Zizi F, Auguste E, Pandi-Perumal SR, Gupta R, Attarian H, Brzezinski A, Hardeland R, McFarlane SI (2017) Sleep, Melatonin, and the Menopausal Transition: What Are the Links? Sleep Sci. Jan-Mar;10(1):11-18. doi: 10.5935/1984-0063.20170003.

Qasrawi SQ, Albarrak AM, Alharbi AS, Nashwan S, Almeneessier AS, Pandi-Perumal SR, Alsaadi MM, BaHammam AS. Narcolepsy in Saudi patients before and after the 2009 H1N1 vaccination. The experience of 2 referral centers. Saudi Med J. 2017 Dec;38(12):1196-1200. doi: 10.15537/smj.2017.12.21046.

Almeneessier AS, Hersi A, Alasousi N, Sharif M, Pandi-Perumal SR, BaHammam AS. (2017) Prevalence and Predictors of Arrhythmia in Patients with Obstructive Sleep Apnea. Sleep Science (Status: Accepted)

BaHammam AS, Almeneessier AS, Pandi-Perumal SR. (2017) Medieval Islamic Scholarship and Writings on Sleep and Dreams. Ann Thorac Med. 13:72-5.

Monti JM, Torterolo P, Spence DW, Pandi-Perumal SR. (2017) Selective serotonin 5-HT2A receptor antagonists and inverse agonists specifically promote slow wave sleep (Stage N3) in man. Sleep and Vigilance. https://doi.org/10.1007/s41782-017-0024-7.

Zaki NFW, Spence DW, BaHammam AS, Pandi-Perumal SR, Cardinali DP, Brown GM. (2017) Chronobiological theories of mood disorder:. Eur Arch Psychiatry Clin Neurosci. 2017 Sep 11. doi: 10.1007/s00406-017-0835-5. .

BaHammam AS, Singh TD, Gupta R, Pandi-Perumal SR. (2017) Choosing the proper interface for positive airway pressure therapy in patients with acute respiratory failureRespir Care. 2017 Oct 31. pii: respcare.05787. doi: 10.4187/respcare.05787.

Manzar MD, Salahuddin M, Maru TT, Dadi TL, Abije MG, Abatneh DD, Pandi-Perumal SR, BaHammam AS. (2017) Sleep correlates of substance use in community-dwelling Ethiopian adults. Sleep Breath. 2017 Sep 7. doi: 10.1007/s11325-017-1567-5.

Manzar MD, Salahuddin M, Sony P, Maru TT, Pandi-Perumal SR, Moscovitch A, Bahammam AS. (2017) Sleep disturbances and memory impairment among pregnant women consuming Khat: An under-recognized problem. Ann Thorac Med. DOI:10.4103/atm.ATM_24_17.

Manzar MD, Sony P, Salahuddin M, Kumalo A, Seithikurippu R. Pandi-Perumal SR, Moscovitch A, Bahammam AS (2017) Electrolyte imbalance and sleep problems during anti-retroviral therapy: An under-recognized problem. Sleep Sci. 10(2):64-67.

Pandi-Perumal SR, Abumuamar AM, Spence DW, Chattu VK, Moscovitch A, BaHammam AS (2017) Racial/ethnic and social inequities in sleep medicine: the tip of the iceberg? J Natl Med Assoc. (Status: published)

Salahuddin M, Tesfaye T, Kumalo A, Pandi-Perumal SR, Bahammam AS, Manzar MD (2017) Validation of the Pittsburgh Sleep Quality Index in community-dwelling Ethiopian adults. Health Qual Life Outcomes (Status: Accepted)

Almeneessier AS, Bahammam AS, Sharif MM, Bahammam SA, Nashwan SZ, Pandi Perumal SR, Cardinali DP, Alzoghaibi M.The influence of intermittent fasting on the circadian pattern of melatonin while controlling for caloric intake, energy expenditure, light exposure, and sleep schedules: A preliminary report. Ann Thorac Med 2017;12:183-90.

Almeneessier AS, Nashwan SZ, Al-Shamiri MQ, Pandi-Perumal SR, BaHammam AS. Erratum to the prevalence of pulmonary hypertension in patients with obesity hypoventilation syndrome: a prospective observational study. J Thorac Dis. 2017 Jul;9(7):E658-E659. doi: 10.21037/jtd.2017.06.140. PMID: 28840038.

Almeneessier AS, Nashwan SZ, Al-Shamiri MQ, Pandi-Perumal SR, BaHammam AS. The prevalence of pulmonary hypertension in patients with obesity hypoventilation syndrome: a prospective observational study. J Thorac Dis. 2017 Mar;9(3):779-788. doi: 10.21037/jtd.2017.03.21.

BaHammam AS, Pandi-Perumal SR, Spence DW, Moscovitch A, Streiner DL (2017) The SAVE trial: has the importance of CPAP for preventing cardiovascular events been discounted? Sleep Vigilance (2017) 1:47–48. DOI 10.1007/s41782-017-0003-z.

Gupta R, Pandi-Perumal SR, BaHammam AS (2017) Hypersomnolence and Traffic Safety. Sleep Med Clin. 2017 Sep;12(3):489-499. doi: 10.1016/j.jsmc.2017.03.018.

Gupta R, Pandi-Perumal SR (2017) Editorial - I. Inaugural issue of Sleep and Vigilance: prospects and promises. Sleep and Vigilance (Status: Accepted)

Grant AB, Williams NJ, Pandi-Perumal SR (2017) Non-adherence to antihypertensive medications in adults with high risk for obstructive sleep apnea. J Clin Hypertens (Greenwich) (Status: published). DOI: 10.1111/jch.12990.

Qasrawi SO, Pandi-Perumal SR, BaHammam AS. The effect of intermittent fasting during Ramadan on sleep, sleepiness, cognitive function, and circadian rhythm. Sleep Breath. 2017 Feb 11. doi: 10.1007/s11325-017-1473-x. PMID: 2819016.

Monti J, Spence DW, Buttoo K, Pandi-Perumal SR (2017) Zolpidem’s use for insomnia. Asian J Psychiatry 2: 79-90. http://dx.doi.org/10.1016/j.ajp.2016.10.006

Aytaman A, Ojike N, Zizi S, Pandi-Perumal SR, Lukolic I, Bhanvadia A, Nwamaghinna F, Kamran H, Akivis A, Bankole O, Salifu MO, McFarlane SI (2016) Hepatitis B Vaccination Rate in Patients with Diabetes: Assessment of Racial and Socioeconomic Disparity. Int J Clin Endocrinol Metab 2(1): 024-027.

Jehan S, Auguste E, Hussain M, Pandi-Perumal SR, Brzezinski A, Gupta R, Attarian H, Jean-Louis G, McFarlane SI. (2016) Sleep and Premenstrual Syndrome. J Sleep Med & Disord. (Status: accepted).

Manzar MD, Zannat w, Hussain ME, Pandi-Perumal SR, BaHammam AS, Barakat D, Ojike NI, Olaish AH, Spence DW. (2016) Dimensionality of the Pittsburgh Sleep Quality Index in the young collegiate adults. SpringerPlus 2016, 5:1550; DOI: 10.1186/s40064-016-3234-x.

Manzar MD, Zanna W, Moiz JA, Bahammam AS, Barakat D, Ojike NI, Pandi-Perumal SR, Hussain ME (2016) Factor scoring models of the Pittsburgh Sleep Quality Index: a comparative confirmatory factor analysis. Biol Rhythms Res.  DOI:10.1080/09291016.2016.1202375.

Hussain ME, Sarwar AHMG, Alam MS, Noohu MM, Zannat W, Pandi-Perumal SR, Bahammam AS, Manzar MD (2016) Polysomnographic correlates of inflammatory complement components in young healthy males. Sleep Science Volume 9(2): April–June 2016, Pages 123–127.

Pandi-Perumal SR, BaHammam AS, Ojike NI, Akinseye OA, Kendzerska T, Buttoo K, Dhandapany PS, Brown GM, Cardinali DP. Melatonin and Human Cardiovascular Disease. J Cardiovasc Pharmacol Ther. 2016 Jul 21. pii: 1074248416660622.

Zaki NFW, Denewar KAF, El Sherif MAF, Elweheid A, Ibrahim HF, Pandi-Perumal SR (2016) Psychological Correlates of Shift Work Sleep Disorder among a Sample of Egyptian Nurses. The Arab J Psychiatry. 27(2): 127-43.

Manzar MD, Muntafa RM, Zannat W, Pandi-Perumal SR, BaHammam AS, Hussain ME (2016) Spontaneous K-complex density in slow wave sleep. PLoS One. 2016 Mar 10;11(3):e0150929. doi: 10.1371/journal.pone.0150929.

Monti JM, Torterolo P, Pandi-Perumal SR (2016) The effects of second generation antipsychotic drugs on sleep variables in healthy subjects and patients with schizophrenia. Sleep Med Rev. 2016 May 15. pii: S1087-0792(16)30014-4. doi: 10.1016/j.smrv.2016.05.002.


BaHammam AS, Pandi-Perumal SR, Piper A, Bahammam SA, Almeneessier AS, Oliash A, Javaheri S. (2016) Gender differences in patients with obesity hypoventilation syndrome. J Sleep Res. 2016 Mar 18. doi: 10.1111/jsr.12400.

Pandi-Perumal SR, Gonfalone AA (2016) Sleep in space as a new medical frontier: the challenge of preserving normal sleep in the abnormal environment of space missions. Sleep Sci. 2016 Jan-Mar;9(1):1-4. doi: 10.1016/j.slsci.2016.01.003.

Akinseye O, Ojike NI, Akinseye LI, Dhandapany PS, Pandi-Perumal SR (2016) Association of Sleep Duration with Stroke in Diabetic Patients: Analysis of the National Health Interview Survey. J Stroke Cerebrovasc Dis. 25(3): 650-655. PMID: 26738814. doi: 10.1016/j.jstrokecerebrovasdis.2015.11.023.

Gupta R, Dhyani M, Kendzerska T, Pandi-Perumal SR, BaHammam AS, Srivanitchapoom P, Hallett M (2015) Restless legs syndrome and pregnancy: prevalence, possible pathophysiological mechanisms and treatment. Acta Neurol Scand. 2015 Oct 19. doi: 10.1111/ane.12520. PMID: 26482928.

BaHammam AS, Pandi-Perumal SR, Alzoghaibi M (2015) The Effect of Ramadan Intermittent Fasting on Lipid Peroxidation in Healthy Young Men while Controlling for Diet and Sleep: A pilot study. Ann Thorac Med. 2016 Jan-Mar;11(1):43-8. doi: 10.4103/1817-1737.172296. PMID: 26933456.

Refinetti R, Sani M, Jean-Louis G, Pandi-Perumal SR, Durazo-Arvizu RA, Dugas LR, Kafensztok R, Bovet P, Forrester TE, Lambert EV, Plange-Rhule J, Luke A (2015)  Evidence for Daily, Weekly and Seasonal but not Lunar Rhythmicity of Physical Activity in a Large Cohort of Individuals from Five Different Countries. Ann Med. 2015 Sep 24:1-8. PMID: 26402449.

Seixas A, Nunes J, Airhihenbuwa C, Williams NJ, Pandi-Perumal SR, James C, Jean-Louis G (2015) Linking Emotional Distress to Unhealthy Sleep Duration: Analysis of the 2009 National Health Interview Survey. Neuropsychiatr Dis Treat. 2015 Sep 25;11:2425-30. doi: 10.2147/NDT.S77909. eCollection 2015. PMID: 26442563.

Manzar MD, Rajput MM, Zannat W, Hameed UA, Spence DW, Pandi-Perumal SR, BaHammam AS,  Hussain ME (2015) Association between sleep quality and inflammatory complement components in collegiate males. Sleep Breath. 2016 May;20(2):867-72. doi: 10.1007/s11325-015-1249-0. PMID: 26354106.

Jehan S, Masters-Israilov A, Salifu I, Zizi F, Jean-Louis G, Pandi-Perumal SR, Gupta R, Brzezinski A, McFarlane SI (2015) Sleep disorders in postmenopausal women. J Sleep Disord Ther. 2015 Aug;4(5). pii: 1000212. PMID: 26512337.

Grigsby-Toussaint DS, Turi KN, Krupa M, Williams NJ, Pandi-Perumal SR, Jean-Louis G. Sleep insufficiency and the natural environment: Results from the US Behavioral Risk Factor Surveillance System survey. Prev Med. 2015 Jul 17;78:78-84. doi: 10.1016/j.ypmed.2015.07.011. PMID: 26193624.

BaHammam AS, Kendzerska T, Gupta R, Ramasubramanian C, Neubauer DN, Narasimhan M, Pandi-Perumal SR, Moscovitch A (2015) Comorbid depression in obstructive sleep apnea: an under-recognized association. Sleep Breath. 2015 Jul 9. PMID: 26156890.

Sani M, Refinetti R, Jean-Louis G, Pandi-Perumal SR, Durazo-Arvizu RA, Dugas LR, Kafensztok R, Bovet P, Forrester TE, Lambert EV, Plange-Rhule J, Luke A (2015) Daily Activity Patterns of 2,316 Men and Women from Five Countries Differing in Socioeconomic Development. Chronobiol Int. 2015 Jun 2:1-7. PMID: 26035482

Golombek DA, Pandi-Perumal SR, Brown GM, Cardinali DP (2015) Some implications of melatonin use in chronopharmacology of insomnia. Eur J Pharmacol. 2015 May 21;762:42-48. doi: 10.1016/j.ejphar.2015.05.032. PMID: 26004526.

Manzar D, Moiz JA, Zannat W, Spence DW, Pandi-Perumal SR, BaHammam AS, Ejaz Hussain M (2015) Validity of the Pittsburgh Sleep Quality Index in Indian University Students. Oman Med J. 2015 May;30(3):193-202. doi: 10.5001/omj.2015.41. PMID: 26171126.

Pandi-Perumal SR, Akhter S, Zizi F, Jean-Louis G, Ramasubramanian C, Edward Freeman R, Narasimhan M,  (2015) Project Stakeholder Management in the clinical research environment: how to do it right. Front Psychiatry. 2015 May 18;6:71. doi: 10.3389/fpsyt.2015.00071. 

Akinseye OA, Williams SK, Seixas A, Pandi-Perumal SR, Vallon J, Zizi F, Jean-Louis G (2015) Sleep As a Mediator in the Pathway Linking Environmental Factors to Hypertension: A Review of the Literature. Int J Hypertens. 2015;2015:926414. doi: 10.1155/2015/926414. PMID: 25821594.

Hardeland R, Cardinali DP, Brown GM, Pandi-Perumal SR (2015) Melatonin and brain inflammaging. Prog Neurobiol. 2015 Apr;127-128C:46-63. doi: 10.1016/j.pneurobio.2015.02.001. 

Ramos AR, Wallace DM, Pandi-Perumal SR, Williams NJ, Castor C, Sevick MA, McFarlane SI, Jean-Louis G (2015) Associations between sleep disturbances and diabetes mellitus among blacks with metabolic syndrome: results from the Metabolic Syndrome Outcome Study (MetSO). Ann Med. 2015 Apr 9:1-5.

Masters-Israilov A, Pandi-Perumal SR, Seixas A, Jean-Louis G, McFarlane SI (2015) Melatonin, the hormone of darkness: from sleep promotion to Ebola treatment. Brain Disord Ther. 2014;4(1). pii: 1000151. 

Agudelo HAM, Correa UJ, Sierra JC, Pandi Perumal SR, Schenck C (2014) Cognitive behavioral treatment for narcolepsy: can it complement pharmacotherapy? Sleep Science 7:30-42.

Karthikeyan R, Marimuthu G, Ramasubramanian C, Pandi-Perumal SR, Spence DW, BaHammam AS, Cardinali DP, Brown GM (2014) Association of Per3 length polymorphism with bipolar I disorder and schizophrenia. Neuropsychiatr Dis Treat. 2014 Dec 9;10:2325-30. doi: 10.2147/NDT.S73765. eCollection 2014. PMID: 25525361

Ramos AR, Wallace DM, Williams NJ, Spence DW, Pandi-Perumal SR, Zizi F, Jean-Louis G. Association between visual impairment and sleep duration: analysis of the 2009 National Health Interview Survey (NHIS). BMC Ophthalmol. 2014 Oct 1;14(1):115. [Epub ahead of print]

Gupta R, Zalai D, Spence DW, BaHammam AS, Ramasubramanian C, Monti JM, Pandi-Perumal SR (2014) When insomnia is not just insomnia: The deeper correlates of disturbed sleep with reference to DSM-5. Asian J Psychiatr. 2014 Dec;12:23-30.

BaHammam AS, Alkhunizan MA, Lesloum RH, Alshanqiti AM, Aldakhil AM, Pandi-Perumal SR, Sharif MM.  Prevalence of sleep-related accidents among drivers in Saudi Arabia. Ann Thorac Med. 2014 Oct;9(4):236-41. doi: 10.4103/1817-1737.140138.

Karthikeyan R, Marimuthu G, Spence DW, Pandi-Perumal SR, BaHammam AS, Brown GM, Cardinali DP (2014) Should we listen to our clock to prevent type 2 diabetes mellitus? Diabetes Res Clin Pract. 2014 Aug 12. pii: S0168-8227(14)00331-3. doi: 10.1016/j.diabres.2014.07.029.

Bahammam AS, Almushailhi K, Pandi-Perumal SR, Sharif MM (2014) Intermittent fasting during Ramadan: does it affect sleep? J Sleep Res. 2014 Feb;23(1):35-43. doi: 10.1111/jsr.12076. Epub 2013 Aug 12.

Bharti VK, Srivastava RS, Kumar H, Bag S, Majumdar AC, Singh G, Pandi-Perumal SR, Brown GM (2014) Effects of melatonin and epiphyseal proteins on fluoride-induced adverse changes in antioxidant status of heart, liver, and kidney of rats. Adv Pharmacol Sci. 2014;2014:532969. doi: 10.1155/2014/532969. 

Alzoghaibi MA, Pandi-Perumal SR, Sharif MM, BaHammam AS (2014) Diurnal intermittent fasting during Ramadan: the effects on leptin and ghrelin levels. PLoS One. 2014 Mar 17;9(3):e92214. doi: 10.1371/journal.pone.0092214.

Gupta R, Spence DW, BaHammam AS, Monti JM, Pandi-Perumal SR (2014) The association between migraine and restless legs syndrome: an appraisal. Somnologie - Schlafforschung und Schlafmedizin, June 2014, Volume 18, Issue 2, pp 121-126; DOI 90.9007/s99797-013-0650-9.

Karthikeyan R, Marimuthu G, Suriyakumar M, BaHammam AS, Spence DW, Pandi-Perumal SR, Brown GM, Cardinali DP (2013) Per3 length polymorphism in patients with Type 2 Diabetes Mellitus. Horm Mol Biol Clin Investig. 2014 Jun;18(3):145-9. doi: 10.1515/hmbci-2013-0049.

Pandi-Perumal SR, Gupta R,Monti JM (2013) Narcolepsy or Sleep Apnea?: Not Everything is What it Appears to be! Front Neurol. 2013; 4: 152. Published online Oct 8, 2013. doi:  10.3389/fneur.2013.00152. 

BaHammam AS, Nashwan S, Hammad O, Sharif MM, Pandi-Perumal SR (2013) Objective assessment of drowsiness and reaction time during intermittent Ramadan fasting: A case-crossover study. Behav. Brain Funct. 9(1):32. doi: 10.1186/1744-9081-9-32.

de Mello MT, Narciso FV, Tufik S, Paiva T, Spence DW, BaHammam AS, Verster JC, Pandi-Perumal SR (2013) Sleep disorders as a cause of motor vehicle collisions. Int J Preventive Med. 4: 246-257.

Monti JM, BaHammam AS, Pandi-Perumal SR, Bromundt V, Spence DW, Cardinali DP, Brown GM (2013) Sleep and circadian rhythm dysregulation in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 43: 209–216.

Pandi-Perumal SR, BaHammam AS, Srinivasan V, Brown GM, Spence DW, Bharti VK, Kaur C, Hardeland R, Cardinali DP (2013) Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes. Neurotoxicity Res. 23(3): 267-300.

BaHammam AS, Sharif MM, Spence DW, Pandi-Perumal SR (2012) Sleep architecture of consolidated and split sleep due to the dawn (Fajr) prayer among Muslims and its impact on daytime sleepiness. Ann Thorac Med Jan, 7(1): 36-41.

Bharti VK, Srivastava RS, Malik JK, Spence DW, Pandi-Perumal SR, Brown GM (2012) Evaluation of blood antioxidant defense and apoptosis in peripheral lymphocytes on exogenous administration of pineal proteins and melatonin in rats. J Physiol Biochem. 68(2): 237-45.

Bharti VK, Srivastava RS, Subramaian P, Warren Spence D, Pandi-Perumal SR, Brown GM (2011) Cerebral epiphyseal proteins and melatonin modulate the hepatic and renal antioxidant defense of rats. Int J Nephrol. 2011;2011:142896. Epub 2011 May 26.

Verster JC, Spence DW, Shahid A, Pandi-Perumal SR, Roth T (2011) Zopiclone as positive control in studies examining the residual effects of hypnotic drugs on driving ability. Curr Drug Saf. 6(4):209-18.

Srinivasan V, Pandi-Perumal SR, Brzezinski A, Bhatnagar KP, Cardinali DP (2011) Melatonin, immune function and cancer. Recent Pat Endocr Metab Immune Drug Discov. 5(2):109-23. 


Srinivasan V, Cardinali DP, Srinivasan US, Kaur C, Brown GM, Spence DW, Hardeland R, Pandi-Perumal SR (2011) Therapeutic potential of melatonin and its analogs in Parkinson's disease: focus on sleep and neuroprotection. Ther Adv Neurol Disord. 4(5):297-317.

Cardinali DP, Pandi-Perumal SR, Brown GM (2011) Sleep and circadian dysregulation in depressive illness. Clinical Neuropsychiatry  8, 6, 321-38
Srinivasan V, Cardinali DP, Pandi-Perumal SR, Brown GM (2011) Melatonin agonists for treatment of Sleep and Depressive disorders. J Exp Integr Med. 1(3): 149-158

Srinivasan V, Spence DW, Pandi-Perumal SR, Brown GM, Cardinali DP (2011) Melatonin in mitochondrial dysfunction and related disorders. Int J Alzhiemer's Dis. 2011;2011:326320.

Pandi-Perumal SR, Spence DW, Verster JC, Srinivasan V, Brown GM, Cardinali DP, Hardeland R (2011) Pharmacotherapy of Insomnia with Ramelteon: Safety, Efficacy and Clinical Applications. Journal of Central Nervous System Disease 3: 51-65 

Srinivasan V, Brzezinski A, Pandi-Perumal SR, Spence DW, Cardinali DP, Brown GM (2011) Melatonin agonists in primary insomnia and depression-associated insomnia: are they superior to sedative-hypnotics? Prog Neuropsychopharmacol Biol Psychiatry 35(4):913-23.

Hardeland R, Cardinali DP, Srinivasan V, Spence DW, Brown GM, Pandi-Perumal SR (2011) Melatonin: a pleiotropic, orchestrating regulator molecule. Prog Neurobiol. 93(3):350-84.

Srinivasan V, Kaur C, Pandi-Perumal SR, Brown GM, Cardinali DP (2010) Melatonin and its agonist ramelteon in Alzheimer's disease: possible therapeutic value. Int J Alzheimers Dis, Article ID 741974, doi:10.4061/2011/741974

de Almeida EA, Di Mascio P, Harumi T, Spence DW, Moscovitch A, Hardeland R, Cardinali DP, Brown GM, Pandi-Perumal SR (2010) Measurement of Melatonin in Body Fluids: Standards, Protocols, and Procedures. Childs Nerv Syst. 27(6):879-91.

BaHammam A, Pandi-Perumal SR (2010) Interfacing sleep and aging. Front. Neur. 1:132. doi: 10.3389/fneur.2010.00132

Srinivasan V, Singh J, Pandi-Perumal SR, Brown GM, Spence DW, Cardinali DP (2010) Jet lag, Circadian Rhythm sleep disturbances and depression: the role of melatonin and its analogs. Adv Ther. 27(11):796-813.

Srinivasan V, Brzezinski A, Warren Spence D, Pandi-Perumal SR, Hardeland R, Brown GM, Cardinali DP (2010) Sleep, mood disorders and antidepressants: the melatonergic antidepressant agomelatine offers a new strategy for treatment. Psychiatria Fennica. 41:147-58.

Pandi-Perumal SR, Warren Spence D, Brown GM, Thorpy MJ (2010) Great challenges to sleep medicine: problems and paradigms. Front. Neur. 1:7. doi:10.3389/fneur.2010.00007

Srinivasan V, Pandi-Perumal SR, Warren Spence D, Kato H, Cardinali DP (2010) Melatonin in infection and septic shock: Some recent concepts. J Crit Care. 25(4):656.e1-6.

Rosenstein RE, Pandi-Perumal SR, Srinivasan V, Spence DW, Brown GM, Cardinali DP (2010) Melatonin as a therapeutic tool in ophthalmology: implication for glaucoma and uveitis. J Pineal Res. 49(1):1-13.

Srinivasan V, Pandi‐Perumal SR, Warren Spence D, Moscovitch A, Trakht I, Brown GM, Cardinali DP (2010) Potential use of melatonergic drugs in analgesia: mechanisms of action. Brain Res Bull. 81(4-5):3 62-71.

Srinivasan V, Warren Spence D, Moscovitch A, Pandi-Perumal SR, Trakht I, Brown GM, Cardinali DP (2010) Malaria: Therapeutic implications of melatonin. J Pineal Res. 48(1): 1-8.

Srinivasan V, Warren Spence D, Pandi-Perumal SR, Zakharia R, Bhatnagar KP, Brzezinski A (2009) Melatonin and Human Reproduction: Shedding light on the darkness hormone. Gynecol Endocrinol. 28:1-7.

Pandi-Perumal SR, Srinivasan V, Warren Spence D, Moscovitch A, Hardeland R, Brown GM, Cardinali DP (2009) Ramelteon: A review of its therapeutic potential in sleep disorders. Adv Ther. 26(6):613-26.

Monti JM, Warren Spence D, Pandi-Perumal SR, Langer SZ, Hardeland R (2009) Pharmacotherapy of insomnia: focus on Zolpidem Extended Release. Clinical Medicine: Therapeutics 1: 123–140.

Pandi-Perumal SR, Moscovitch A, Srinivasan V, Spence DW, Cardinali DP, and Brown GM (2009) Bidirectional communication between sleep and circadian rhythms and its implications for depression: lessons from agomelatine. Prog Neurobiol. 88(4):264-71.

Srinivasan V, Pandi-Perumal SR, Trahkt I, Spence DW, Poeggeler B, Hardeland R, cardinali DP (2009) Melatonin and melatonergic drugs on sleep: possible mechanisms of action. Int J Neurosci. 119(6):821-46.

Srinivasan V, Pandi-Perumal SR, Trakht I, Spence DW, Hardeland R, Poeggeler B, Cardinali DP (2009) Pathophysiology of depression: role of sleep and the melatonergic system. Psychiatry Res. 165(3):201-14.

Brown GM, Pandi-Perumal SR, Trakht I, Cardinali DP (2009) Melatonin and its Relevance to Jet Lag. Travel Medicine and Infectious Dis. Travel Med Infect Dis. 7(2):69-81.

Sleep and Comorbid Psychiatric Disorders—Part I and Sleep and Psychiatric Disorders: Part II - The Melatonergic System in Psychiatry Weekly

Cardinali DP, Esquifino AI, Srinivasan V, Pandi-Perumal SR (2008) Melatonin and the Immune System in Aging. Neuroimmunomodulation 15(4-6):272-8.

Srinivasan V, Warren Spence D, Pandi-Perumal SR, Trakht I, Cardinali DP (2008) Therapeutic actions of melatonin in cancer: possible mechanisms. Integ Cancer Ther 7(3):189-203.

Pandi-Perumal SR, Trakht I, Warren Spence D, Srinivasan V, Dagan Y, Cardinali DP (2008) The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders. Nature Clinical Practice Neurology 4(8):436-47.

Pandi-Perumal SR, I. Trakht, Srinivasan V, Spence DW, Maestroni GJM, N. Zisapel, Cardinali DP (2008) Physiological Effects of Melatonin: The Role of Melatonin Receptors and Signal Transduction Pathways. Prog. Neurobiol. 85(3):335-53.

Srinivasan V, Spence DW, Trakht I, Pandi-Perumal SR, Cardinali DP, Maestroni GJ (2008) Immunomodulation by melatonin: Its significance for seasonally-occurring diseases. Neuroimmunomodulation 15: 93-101.

Pandi-Perumal SR, Trakht I, Brown GM, Cardinali DP (2008) Melatonin, Circadian dysregulation and sleep in mental disorders. Primary Psychiatry 15(5): 77-82.

Pandi-Perumal SR, Trakht I, Srinivasan V, Spence DW, Poeggeler B, Hardeland R, Cardinali DP (2008) The effect of melatonergic and non-melatonergic antidepressants on sleep: weighing the alternatives. World J Biol Psychiatry 4: 1-13.

Cardinali DP, Pandi-Perumal SR, Srinivasan V, Warren Spence D, Trakht I, (2008) Therapeutic potential of melatonin agonists. Expert Rev Endocrinol Metab. 3(2): 269-79.

Srinivasan V, Spence DW, Pandi-Perumal SR, Trakht I, Cardinali DP (2008) Jet lag and transmeridian travel: the therapeutic use of melatonin and its analogues. Travel Medicine Infectious Disease 6: 17-28.

Subramanian P, Babu Dakshayani K, Pandi-Perumal SR, Trakht I, Cardinali DP (2008) 24-Hour rhythms in oxidative stress during hepatocarcinogenesis in rats: effect of melatonin or α-ketoglutarate. Redox Report 13(2): 78-86.

Hardeland R, Poeggeler B, Srinivasan V, Trakht I, Pandi-Perumal SR, Cardinali DP (2008) Melatonergic drugs in clinical practice. Arzneimittelforschung-Drug Res 2008; 58(1):1-10.

Subramanian P, Mirunalini S, Dakshayani KB, Pandi-Perumal SR, Trakht I, Cardinali DP (2007) Prevention by melatonin of hepatocarcinogenesis in rats injected with N-Nitrosodiethylamine. J. Pineal Res. 43: 305-12.

Subramanian, P, Mirunalini S, Pandi-Perumal SR, Trahkt I, Cardinali DP (2007) Melatonin treatment improves the antioxidant status and decreases lipid content in brain and liver of rats. Eur J Pharmacol 571(2-3):116-9.

Srinivasan V, Spence DW, Pandi-Perumal SR, Trakht I, Esquifino AI, Cardinali DP, Maestroni GJ (2007) Melatonin, Environmental Light, and Breast Cancer. Breast Cancer Res Treatment 108(3):339-50.

Verster JC, Volkerts ER, Spence DW, Alford C, Pandi-Perumal SR (2007) Effects of sleep medications on cognition, psychomotor skills, memory and driving performance in the elderly. Current Psychiatry Rev. 3(4): 281-92.

Monti JM, Pandi-Perumal SR (2007) Expert Opinion - Eszopiclone: its use in the treatment of insomnia. Neuropsychiatric Dis and Treat. 3(3): 1-13.

Hardeland R, Pandi-Perumal SR, Poeggeler B (2007) Melatonin in Plants – focus on a Vertebrate Night Hormone with cytoprotective properties. Func Plant Sci Biotech. (Status: published online)

Pandi-Perumal SR, Srinivasan V, Spence DW, Cardinali DP (2007) Role of the melatonin system in the control of sleep: therapeutic implications. CNS Drugs 21(12):995-1018.

Pandi-Perumal SR, Srinivasan V, Poeggeler B, Hardeland R, Cardinali DP (2007) Drug Insight: The use of melatonergic Agonists for the Treatment of Insomnia: Focus on Ramelteon. Nature Clinical Practice Neurol. 3: 221-28.

Lundmark PO., Pandi Perumal SR., Srinivasan V, Cardinali DP (2007) Role of melatonin in the eye and ocular dysfunctions. Vis Neurosci. 23(6): 853-62.

Lundmark PO, Pandi-Perumal SR., Srinivasan V, Cardinali DP, Rosenstein RE (2006) Melatonin in the eye: implications for Glaucoma. Exp Eye Res. 84(6):1021-30.

Pandi-Perumal SR, Srinivasan V, Cardinali DP, Monti JM (2006) Could agomelatine be the ideal antidepressant? Expert Rev Neurotherapeutics 6: 1595-1606.

Pandi-Perumal SR, Smits MG, Spence, DW, Srinivasan V, Cardinali DP, Lowe AD, Kayumov L (2006) Dim light melatonin onset (DLMO): A tool for the analysis of circadian phase position in human sleep and circadian rhythm studies. Prog. Neuropsychopharmacol Biol Psychiatry 31(1): 1-11.

Srinivasan V, Pandi-Perumal SR, Cardinali DP, Poeggeler B, and Hardeland R (2006) Melatonin in Alzheimer’s and other neurodegenerative disorders. Behav and Brain Funct 2(1): 15.

Hardeland R, Pandi-Perumal SR, Cardinali DP (2006) Molecules in Focus: Melatonin. Int. J. Biochem. Cell Biol. 38(3): 313-16.

Srinivasan V, Smits M, Spence DW, Lowe AD, Kayumov L, Pandi-Perumal SR, Parry BL, Cardinali DP (2006) Melatonin in Mood Disorders. World J Biol Psychiatry 7(3):138-51.

Miller SC, Pandi-Perumal SR, Esquifino AI, Cardinali DP, and Maestroni GJM (2006) The role of melatonin in immunoenhancement: Potential application in Cancer. Int. J. Exp. Path 87: 81-87. (Erratum published in Int J Exp Path 87: 251 (2006)

Pandi-Perumal SR, Srinivasan V, Maestroni G.J.M, Cardinali D.P, Poeggeler B, and R. Hardeland (2006) Melatonin: nature’s most versatile biological signal? FEBS Journal 273: 2813-38.

Pandi-Perumal SR, Verster JC, Kayumov L, Lowe AD, Santana MG, Pires MLN, Tufik S, Mello MT (2006) Sleep Disorders, Sleepiness and traffic safety: a public health menace. Braz J Med Biol Res. 39: 863-71.

Srinivasan V, Pandi-Perumal SR, Maestroni GJM, Esquifino AI, Hardeland R, Cardinali DP (2005) Role of melatonin in neurodegenerative diseases. Neurotox. Res. 7: 293-318.

Pandi-Perumal SR, Zisapel N, Srinivasan V, Cardinali DP (2005) Melatonin and Sleep in Aging Population. Exp. Gerontol. 40(12): 911-25


Maestroni GJM, Cardinali DP, Esquifino AI, and S.R. Pandi-Perumal (2005) Does melatonin play a disease-promoting role in rheumatoid arthritis? J Neuroimmunology 158 (1-2): 106-11.

Srinivasan V, Maestroni GJM, Cardinali DP, Esquifino AI, Pandi-Perumal SR, and Miller SC (2005) Melatonin, Immune function, and Aging. Immunity and Ageing 2(1): 17.

Verster JC,Pandi-Perumal SR, Volkerts ER (2005) Drugged Vs Drowsy Driving Sleep Review, Nov-Dec - 2005

Esquifino AI, Pandi-Perumal S.R. Cardinali DP (2004) Circadian organization of the immune response: a role for melatonin. Clinical and Applied Immunol Rev. 4: 423-33.

Cartwright R, Baehr E, Kirkby J, Pandi-Perumal SR, Kabat J. (2003) REM sleep reduction, mood regulation and remission in untreated depression. Psychiatry Res. 121(2):159-67.

Pandi-Perumal SR, Seils LK, Kayumov L, Ralph MR, Lowe A, Moller H, Swaab DF (2002) Senescence, sleep, and circadian rhythms. Ageing Res. Rev. 32: 559-604.

Kayumov L, Rotenberg V, Buttoo K, Auch C, Pandi-Perumal SR, Shapiro CM (2000) Interrelationships between nocturnal sleep, daytime alertness, and sleepiness: two types of alertness proposed. J Neuropsychiatry Clin Neurosci.  12(1):86-90.

Kayumov L, Pandi-Perumal SR, Fedoroff P, Shapiro CM (2000) Diagnostic values of polysomnography in forensic medicine. J Forensic Sci. 45(1): 191-194.

BOOK CHAPTERS:

Smits M, Brown GM, Cardinali DP, Pandi-Perumal SR. Dim Light Melatonin Onset (DLMO): Clinical and Methodological aspects. In. Kushida C. Encyclopedia of Sleep and Circadian Rhythms. 2nd Edition, Elsevier, 2021. 

Cardinali DP, Brown GM, Pandi-Perumal SR. Chronotherapy. In. Volume 1. The Human Hypothalamus. Part I Hypothalamic systems: Anterior hypothalamus, Swaab DF, Lucassen PJ, Buijs RM (eds.), Handbook of Clinical Neurology, Elsevier, 2021.

BaHammam AS, Neubauer DN, Pandi-Perumal SR. Sleep and Sleep Pharmacology, In: Rau’s Respiratory Care Pharmacology, Gardenhire DS (ed.), 9th edition, USA: Mosby, 2018. (Status: Accepted).

Brown GM, Pandi-Perumal SR, Cardinali DP. Circadian Rhythm Sleep-Wake Disorders. In. Chopra A, Das P, Doghramji K. Management of Sleep Disorders in Psychiatry, Oxford, UK: Oxford University Press, 2018. (Status: Accepted)

Burman D, McCormick S, Pandi-Perumal. Sueño y cognición. In. Cognición y Epilepsia. (In. Spanish), 2018. (Status: Accepted).

Pagel JF, Pandi-Perumal SR. Dreaming and sleep disorder. In. Chokrovery S (ed.). Sleep Disorders Medicine: Basic Science, Technical Considerations, and Clinical Aspects, 4th edition. Ch. 14. Springer Science+Business Media, New York, 2017, p. 225-234.

Goswami M, Pandi-Perumal SR, Buttoo K (2015) Narcolepsy and psychosomatic illnesses. In. Pandi-Perumal SR, Narasimhan M, Kramer M (eds), Sleep and Psychosomatic Medicine, 2nd edition.

Torterolo P, Monti JM, Pandi-Perumal SR (2015) Neuroanatomy and neuropharmacology of sleep and wakefulness. In. Pandi-Perumal SR (ed.), Synopsis of Sleep Medicine, Toronto, Canada: Apple Academic Press.

Neubauer DN, Buttoo K, Pandi-Perumal SR (2015) Pharmacological management of insomnia. In. Pandi-Perumal SR (ed.), Synopsis of Sleep Medicine, Toronto, Canada: Apple Academic Press.

Monti JM, Torterolo P, Pandi-Perumal SR. The Involvement of 5-HT2A Receptor in the Regulation of Sleep and Wakefulness, and the Potential Therapeutic Use of Selective 5-HT2A Receptor Antagonists and Inverse Agonists for the Treatment of an Insomnia Disorder. In. Guiard EP and Di Giovanni G (eds.), The Receptors - 5-HT2A Receptors in the Central Nervous System, New York, USA: Springer/Humana. (Status: submitted)

Pandi-Perumal SR, BaHammam AS, Shapiro CM. Parasomnias. In: Ian P. Stolerman, Lawrence H. Price eds. Encyclopedia of Psychopharmacology, pp.1-10. Publisher: Springer Berlin Heidelberg. DOI: 10.1007/978-3-642-27772-6_316-2 (ISBN: 78-3-642-27772-6), 2015.

BaHammam AS, Neubauer DN, Pandi-Perumal SR. Sodium Oxybate (Xyrem), Guglietta A (ed). Drug Treatment of Sleep Disorders, Series: Milestones in Drug Therapy, New York, USA: Springer, ISBN 978-3-319-11513-9, 2015.

Neubauer DN, BaHammam AS, Pandi-Perumal SR. Tasimelteon, In: Guglietta A (ed.). Drug Treatment of Sleep Disorders, Series: Milestones in Drug Therapy, New York, USA: Springer, ISBN 978-3-319-11513-9, 2015.

Pandi-Perumal SR, Spence DW, BaHammam AS. Polysomnography: an overview “Chapter”. In: Pagel J, Pandi-Perumal SR (eds.), Primary Care Sleep Medicine: a Practical Guide. 2nd edition, Chapter 4; pp.29-42 2nd edition. New York, USA: Springer, 2014, ISBN: 78-1-4939-1184-4; (Print) 978-1-4939-1185-1 (Online).

Pandi-Perumal SR, Neubauer DN, BaHammam AS. Sleep and Sleep Pharmacology, In: Rau’s Respiratory Care Pharmacology, Gardenhire DS (ed.), 9th edition, USA: Mosby, 2014.

Monti JM, Pandi-Perumal SR. Role of zolpidem in the management of primary and comorbid insomnia, In. Advances in the management of primary and secondary insomnia, McCall WV (ed.), London: Future Medicine, 2014. pp. 108, ISBN: 978-1-78084-482-4

Decker MJ, Pandi-Perumal SR, Sinton CM (2010) Sleep and Approaches to Sleep Phamacology. In. Rau's Respiratory Care Pharmacology, Gardenhire DS (ed.), 8th Edition, Mosby, USA.(Status: published)

Brown GM, Pandi-Perumal SR, Trakht I, Warren Spence D, Cardinali DP, Samel A (2010) Melatonin and Treatment of Disorders related to Jet Lag and Shift Work. In: Ronald R. Watson (ed.), Melatonin in the promotion of health, 2nd edition, Informa Healthcare, UK. (Status: published)

Pandi-Perumal SR, D. Warren Spence D, Shelby Freedman Harris, Thorpy MJ, Kramer M (2010) PARASOMNIAS, In. Encyclopedia of Psychopharmacology. Stolerman, Ian P.(ed.). Springer-Verlag, UK.

Cardinali DP, Pandi-Perumal SR, Niles LP, Brown GM (2010) Melatonin and sleep: Possible involvement of GABAergic mechanisms. In. GABA and Sleep: Basic Mechanisms, Pathophysiological, Pharmacological and Therapeutic Aspects, Eds. Monti JM, Pandi-Perumal SR, Mohler H, Basel, Switzerland: Birkhauser Verlag AG.

Smits MG, Pandi-Perumal SR, Warren Spence D, Brown GM (2009) Dim Light Melatonin Onset (DLMO) in psychiatric disorders. In. Pandi-Perumal SR, Kramer M (eds.), Sleep and Mental Illness, Cambridge, England: Cambridge University Press.

Brown GM, Cardinali DP, Pandi-Perumal SR (2009) Melatonin and Mental Illness, In: Pandi-Perumal SR, Kramer M (eds.), Sleep and Mental Illness, Cambridge, England: Cambridge University Press.

Michal Karasek, Seithikurippu R Pandi-Perumal: Rozdzial 11. Starzenie sie a rytmy biologiczne. W: Karasek M, red. Aspekty Medyczne Starzenia sie Czlowieka. Lodz: Lodzkie Towarzystwo Naukowe, 2008 (to be published in Polish). (Michal Karasek, Seithikurippu R Pandi-Perumal: Chapter 11. Aging and biological rhythms. In: Karasek M, ed. Medical Aspects of Human Aging. Lodz: Lodzkie Towarzystwo Naukowe, 2008)

Brown GM, Pandi-Perumal SR, Trakht I, Cardinali DP (2009) The Role of Melatonin in Seasonal Affective Disorder. In. Seasonal Affective Disorder, Partonen T, Pandi-Perumal SR (editors), 2nd edition, Oxford, England: Oxford University Press

Partonen M, Spence DW, Pandi-Perumal SR (2009) Sleep in Sesonal Affective Disorder. In. Sleep and Mental Illness, Pandi-Perumal SR, Kramer M (eds.), Cambridge, England: Cambridge Unviersity Press

S.R. Pandi-Perumal, D. Warren Spence, and Vijay Kumar Sharma (2009) Aging and Circadian Rhythms: general trends. In. Principles and Practice of Geriatric Sleep Medicine, Pandi-Perumal SR, Monti JM, Monjan AA (eds).

V. Srinivasan, SR Pandi-Perumal, A.I. Esquifino, G.J.M. Maestroni, D.P. Cardinali (2008) Melatonin, Immune Function and Cancer, In: Cancer and Rhythms, Springer-Verlag

Srinivasan V, Pandi-Perumal SR, Spence DW, Smits MG, van der Heijden KB, Cardinali DP (2008) Melatonin in attention-deficit hyperactivity disorder.In. Ivanenko A (ed). Sleep and Psychiatric Disorders in Children and Adolescents, Informa Healthcare.

S.R. Pandi-Perumal, P. Subramanian, I. Trakht, D.P. Cardinali (2008) Chronopharmacology: principles and applications in sleep medicine, In: Sleep Disorders: Diagnosis and Therapeutics, S.R.Pandi-Perumal, J.C. Verster, J.M. Monti, M. H. Lader, S. Langer (eds.), Informa Healthcare, UK, pp. 153-62.

J.M. Monti, S.R. Pandi-Perumal, S.Z. Langer (2008) Zolpidem: its use in the treatment of sleep disorders, In: Sleep Disorders: Diagnosis and Therapeutics, S.R.Pandi-Perumal, J.C. Verster, J.M. Monti, M. H. Lader, S. Langer (eds.), Informa Healthcare, UK, pp. 295-323.

Cardinali DP, Pandi-Perumal SR,Srinivasan V (2008) Circadian control by serotonin and melatonin receptors: clinical relevance. In. Serotonin and Sleep: Molecular, Functional, and Clinical Aspects, Monti JM, Pandi-Perumal SR, Jacobs BL, Nutt DJ (eds.), Basel, Switzerland; Birkhäuser-Verlag, pp. 477-99.

V. Srinivasan, S.R. Pandi-Perumal, Warren Spence, D.P. Cardinali, M.G. Smits (2008) Melatonin and Quality of Life. In. Sleep and Qualilty of Life in clinical Medicine, J.C. Verster, S.R. Pandi-Perumal, D.L. Streiner (eds.), Humana Press/Springer, p.67-77.

T. Harumi, S. R. Pandi-Perumal., G. R. Martinez., P. Di Mascio and Y. Hayashi (2007) Chromatographic Analyses of Biogenic Melatonin and Its Related Indoleamines. In. Melatonin: From Molecules to Therapy, S.R. Pandi-Perumal and D.P. Cardinali (eds.), Nova Science Publishers, USA.

V. Srinivasan, S. R. Pandi-Perumal, W. Spence., L. Kayumov and D. P. Cardinali (2007) Melatonin and sleep in shift-workers. In. Melatonin: From Molecules to Therapy, S.R. Pandi-Perumal and D.P. Cardinali (eds.), Nova Science Publishers, USA.

S. R. Pandi-Perumal, W. Spence, A. D. Lowe, L. Kayumov, D. P. Cardinali, T. Partonen and A. A. Putilov (2007) Sleep and Circadian Neuroendocrine Dysregulation in Seasonal Affective Disorder. In. Melatonin: From Molecules to Therapy, S.R. Pandi-Perumal and D.P. Cardinali (eds.), Nova Science Publishers, USA.

Cardinali DP, Esquifino AI, Maestroni GJM, Pandi-Perumal SR (2007) Circadian organization of immune response: lessons from the adjuvant arthritis model. In. Neuroimmunology of Sleep, Pandi-Perumal SR, Cardinali DP, Chrousos GP (eds.), New York, USA: Springer-Verlag, pp. 59-84.

Cardinali DP, Pandi-Perumal SR, Niles LP (2007) Melatonin and its receptors: biological function in circadian sleep/wake regulation. Monti JM, Pandi-Perumal SR, Sinton CM (eds.), Neurochemistry of Sleep, Cambridge, England: Cambridge University Press, pp. 197-206.

Goswami M, Pandi-Perumal SR. (2007) Narcolepsy: Psychosocial, Socioeconomic, and Public Health Considerations. Pandi-Perumal SR, Ruoti R, Kramer M (eds.), Sleep and Psychosomatic Medicine, Oxford, England: Informa Healthcare, pp. 191-205.

Cardinali DP and SR Pandi-Perumal (2006) Chronopharmacology and its implications to the pharmacology of sleep. In: Pandi-Perumal SR, Monti JM (eds.). Clinical Pharmacology of Sleep, Basel, Switzerland: Birkhauser-Verlag AG.

Nagayama H, Cornelissen G, Pandi-Perumal SR, Halberg F (2006) Time-dependent psychotropic drug effects: hints of pharmacochronomics, broader than circadian time structures. In: Lader M, Cardinali DP, and Pandi-Perumal SR (eds.). Sleep and Sleep Disorders: a neuropsychopharmacological approach. Landes Bioscience, USA. ISBN: 0-387-27681-5, Chapter 7, pp. 55-94.

Martins da Silva A, Mendez M, Bai C, and S.R. Pandi-Perumal (2006) Sleep and Epilepsy: From Interrelationships to Influence of Antiepileptic Drugs. In: Lader M, Cardinali DP, and Pandi-Perumal SR (eds.). Sleep and Sleep Disorders: a neuropsychopharmacological approach. Landes Bioscience, USA. ISBN: 0-387-27681-5, Chapter 7, pp. 282-96.

Esquifino AI, Pandi-Perumal SR, Maestroni GJM, Cardinali DP (2006) Chronobiology of the immune system, In. Neuroimmunology of Sleep, Pandi-Perumal SR, Cardinali DP, G Chrousos (eds.). New York, USA: Springer-Verlag

Putilov AA, Pandi-Perumal SR, and T. Partonen (2005) Sleep and Circadian neuroendocrine function in seasonal affective disorder. In: Cardinali DP and Pandi-Perumal SR (eds.). Neuroendocrine Correlates of Sleep/wakefulness, New York: Springer-Verlag. ISBN: 0-387-23641-4, p. 553-87.

Srinivasan V, Smits MG, Kayumov L, Pandi-Perumal SR, Cardinali DP, Thorpy MJ (2005) Melatonin in circadian rhythm sleep disorders. In: Cardinali DP and Pandi-Perumal SR (eds.). Neuroendocrine Correlates of Sleep/wakefulness, New York: Springer-Verlag. ISBN: 0-387-23641-4, p. 269-94.

Putilov AA, Russkikh GS and S.R. Pandi-Perumal (2003) Chronophysiology of SAD: melatonin in Winter Depression. In. Melatonin: Biological Bases of its Function in Health and Disease. S.R. Pandi-Perumal and D.P. Cardinali (eds.), Landes Bioscience, USA. ISBN: 1-58706-244-5. p. 253-62.

M.G. Smits, and S.R. Pandi-Perumal (2003) Delayed Sleep Phase Syndrome: a melatonin onset disorder. In. Melatonin: Biological Bases of its Function in Health and Disease. S.R. Pandi-Perumal and D.P Cardinali (eds), Landes Bioscience, USA. ISBN: 1-58706-244-5. p. 263-72.

Paccherotti C, Iapichino S, Bossini L, Pieraccini F, Castrogiovanni P, and S.R. Pandi-Perumal (2002) Melatonin: Psychiatric perspectives. (Chapter 25, pp. 445-58). In. Treatise on Pineal Gland and Melatonin. (eds.), C. Haldar, M. Singaravel and S.K. Maitra. Science Publishers, Inc., Enfield, NH (ISBN: 1-57808-225-0).

Benitez-King G, Hernandez ME, Ramirez G, Pandi-Perumal SR, Ortega-Soto HA (2002) Melatonin effects on cytoskeletal organization: implications for brain function and disease. (Chapter 28, pp. 507-19). In. Treatise on Pineal Gland and Melatonin. (eds.), C. Haldar, M. Singaravel and S.K. Maitra. Science Publishers, Inc., Enfield, NH (ISBN: 1-57808-225-0).

Conti A, Tettamanti C, Singaravel M, Halder C, Pandi-Perumal SR, Maestroni GJM (2002) Melatonin: an ubiquitous and evolutionary hormone. (Chapter 6, pp. 103-43). In. Treatise on Pineal Gland and Melatonin. (eds.), C. Haldar, M. Singaravel and S.K. Maitra. Science Publishers, Inc., Enfield, NH (ISBN: 1-57808-225-0).

Singaravel M, Conti A, Pandi-Perumal SR, Tettamanti C, Maestroni GJM, Haldar C (2002) Melatonin administration: time and dose determine the rate of re-entrainment of the circadian rhythm in the mammalian system. (Chapter 17, 323-38). In. Treatise on Pineal Gland and Melatonin. (eds.), C. Haldar, M. Singaravel and S.K. Maitra. Science Publishers, Inc., Enfield, NH (ISBN: 1-57808-225-0).

Claustrat B, Pandi-Perumal SR, Kayumov L (2002) Dual role of melatonin in humans: a hormone and a chronobiotic drug? (Chapter 31, 541-51). In. Pineal Gland and Melatonin. (eds.), C. Haldar, M. Singaravel and S.K. Maitra. Science Publishers, Inc., Enfield, NH (ISBN: 1-57808-225-0). In. Treatise on Pineal Gland and Melatonin. (eds.), C. Haldar, M. Singaravel and S.K. Maitra. Science Publishers, Inc., Enfield, NH (ISBN: 1-57808-225-0).

ABSTRACTS:


Ojike N, Sunil Penesetti S, Azizi Seixas A, Pandi-Perumal SR, McFarlane SI, Ogedegbe G, Jean-Louis G. Should patients with hypertension be screened for psychological distress? Journal of the American Society of Hypertension, Volume 9, Issue 4, Supplement, April 2015, Page e68.

Ojike N, Penesetti S, Grant A, Zizi F, Pandi-Perumal SR, Ogedegbe G, McFarlane SI, Jean-Louis G. Race and age group differences in wellness evaluation among individuals with hypertension. Journal of the American Society of Hypertension, Volume 9, Issue 4, Supplement, April 2015, Pages e68-e69.

Grant AM, Seixas A, Butler M, Ojike N, Pandi-Perumal SR, Frederickson K, Tobin JN, Jean-Louis G, Ogedegbe G. Perceptions of care on anti-hypertensive medications adherence among blacks. Journal of the American Society of Hypertension, Volume 9, Issue 4, Supplement, April 2015, Page e107.

 Zaheer S, Rogers A, Racine C, Donat M, Pandi-Perumal SR, Zizi F, Ogedegbe G, Jean-Louis G (2015) Risk of obstructive sleep apnea among blacks with metabolic syndrome. APSS 2015, Seattle, USA.

Ojike N, Masters-Israilov A, St.Laurent-Ariot K, Zaheer S, Rosenthal D, Weatherhead K, Pandi-Perumal SR, Zizi F, Jean-Louis G, McFarland SI (2015) Association between emotional distress, sleep, and diabetes: analysis of The National Health Interview Survey Data. APSS 2015, Seattle, USA.

Sani M, Refinetti R, Jean-Louis G, Pandi-Perumal SR, Durazo-Arvizu RA, Dugas LR, Kafensztok R, Bovet P, Forrester TE, Lambert EV, Plangue-Rhule J, Luke A (2015) Daily activity patters of 2,213 men and women from five nations differing in socioeconomic development. APSS 2015, Seattle, USA.

Vallon J, Williams NJ, Zaheer S, Casimir G, Zizi F, Pandi-Perumal SR, Ogedegbe G, jean-Louis G (2014) Sleep parameters among Blacks with metabolic syndrome, In. International Symposium on Minority Health & Health Disparities (ISMHHD) - Transdisciplinary collaborations: evolving dimensions of US and Global health equity (Dec 1-3, 2014)

Williams NJ, Weatherhead K, Collymore J, Pandi-Perumal SR, Zizi F, Ogedegbe G,  Jean-Louis G (2014) Increase adherence to sleep apnea intervention among blacks with metabolic syndrome. In. International Symposium on Minority Health & Health Disparities (ISMHHD) - Transdisciplinary collaborations: evolving dimensions of US and Global health equity (Dec 1-3, 2014)

Addison D, Williams NJ, Castor C, Weatherhead K, Collymore J, Seixas A, Pandi-Perumal SR, Nunes J, Jean-Louis G (2014) Bias of reporting sleep problems among blacks, APSS.

Marsan R, Williams NJ, Racine C, Casimir G, Pandi-Perumal SR, Zizi F, Ogedegbe G, Jean-Louis G (2014) Sleep Characteristics among blacks with metabolic syndrome, APSS.

Noce F, Tufik S, Verster JC, Perumal SRP, Spence DW, Trakht I (2007) Commercial Driver: Working hours, rest and acidents. XI Congresso Brasileiro de Sono, 11-14th November 2007, Sao Paulo, Brazil (abstract)

Pandi-Perumal Sr, Kirkby J, Cartwright R (2003) Delta sleep changes in untreated depression. Sleep 26: A376.

Cartwright RD, Kirkby J, Pandi-Perumal SR, Baehr E, Mercer P, Newell P (2003) Prediction of remission from untreated depression. Sleep 26: A373.

Pandi-Perumal SR, Seils LK, Singaravel M, Haldar C (2002) Melatonin administration in mammals: simulation of jet lag and shift work. In. IInd Indian Pineal Study Group (IPSG) symposium on, 'Neuroendocrine system and pineal gland with special reference to livestock, 1-3rd March, organized by the Division of Physiology and Climatology, Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh - 243 122, p: 33-34.

Kayumov L, Lowe A, Kotalyar B, Pandi-Perumal SR, Simkhovich, Shapiro CM (2002) EEG and brain music neuro-feedback method. In. 16th congress of the European Sleep Research Society, Reykjavik, June 3-, J. Sleep Res. 11 (suppl.1): 118-19.

Putilov AA, Palchikov VE, Danilenko KV, Pandi-Perumal SR, Kayumov L (2002) Non-REMS pressure in the day- and nighttime sleep in winter depression. Sleep 25: A190.

Fung SJ, Yamuy J, Xi MC, Pandi-Perumal SR, Morales FR, Chase MH (2001) Intracellular study of excitability changes in hypoglossal motoneurons during naturally-occurring active sleep. In. Sleep Odyssey: World Conference on the 'Physiological Basis for Sleep Medicine', Punta del Este, Uruguay, October 21-26. Acta de Fisiologia 7: 173.

Rial RV, Nicolau MC, Gamundi A, Akaarir M, Pandi-Perumal SR (2001) Functions of Sleep: Simplicity versus complexity. In. Sleep Odyssey: World Conference on the 'Physiological Basis for Sleep Medicine', Punta del Este, Uruguay, October 21-26. Acta de Fisiologia 7: 142.

Fung SJ, Yamuy J, Xi MC, Pandi-Perumal SR, Morales FR, Chase MH (2001) Cat hypoglossal motoneurons are postsynaptically inhibited during naturally-occurring active sleep. Soc. Neurosci. abstract.

Pandi-Perumal SR, Timofeev I, Bazhenov M, Sejnowski T, Steriade M (2000) Cortical Ih takes part in the generation of paroxysmal activities. Soc. Neurosci. Abstr. 30(2): 1779 (abstr number. 661.7)

Pandi-Perumal SR, Amzica F, Steriade M (1999) Higher propensity of Association vs. Primary Visual Cortices to the genesis of slow sleep oscillations. Soc Neuro Sci Abstr. 25(1): 361 (abstr no. 145.6).

Hussain N, Kayumov L, Pandi-Perumal SR, Bhuttoo K, Rotenberg V, Shapiro CM (1999) Two types of alertness in depression and sleep apnea, APSS, Orlando, FL, USA. c505.L Sleep 1999; 22 (suppl.1): 307.

Kayumov L, Auch C, Pandi-Perumal SR, Rotenberg V, Shapiro CM (1998) Sleep and Alertness in Depression. In. Euro Conference on Psychosomatic Research, Manchester, England.

Pandi-Perumal SR, Prem Kumar A, Sathink MBM, Barnabas AD (1990) Diurnal fluctuation of proline level in scrub jungle trees. In. International Symposium on Current Status of Chronobiology and VIII Biennial meeting of Indian Society for Chronobiology conducted by the Department of Biosciences, Ravishankar University, Raipur, India, Nov 24-26, p. 59.

CONFERENCE ATTENDED:

October 21-26, 2001. World Conference on, '2001 Sleep Odyssey: Physiological Basis for Sleep Medicine', organized by World Federation of Sleep Research Societies (WFSRS) and Latin American Sleep Society (LASS), Montevideo, Uruguay.

October 18-19, 2001. Symposium on 'Stressor-induced alterations in sleep' jointly organized by the American Physiological Society and the Department of Psychobiology, Universidade Federal de Sao Paulo, Brazil.

July 13-15, 1997. The 5th Canadian Pineal and Melatonin Symposium, organized by the University of Guelph, ON, Canada.

July 28-31, 1990. first International Conference on Bacillus Thuringiensis (Bt-91), organized by the National and Environmental Research Council (NERC) and the Institute of Virology and Environmental Microbiology, University of Oxford, Mansfield Road, Oxford OX1 3SR, England.

April 27-29, 1989. International Conference on the Biology and Control of Pests of Agricultural and Medical Importance, organized by the Post-Graduate and Research Department of Zoology, The American College, Madurai 625 002, India.

SPECIALIZED TRAINING COURSES:

Sept-24-29, 2002. The interaction between Sleep and other disciplines - Sleep Training Workshop organized by the University of California, Los Angeles at Lake Arrowhead, CA, USA.

March 12, 2002. Certificate of Attendance in 'Human Research Protections' issued by Rush-Presbyterian-St. Luke's Medical Center, 1653 West Congress Parkway, Chicago, Illinois 60612.

Jan 31, 2002. Clinical Trials Training: Budget Workshop, organized by the Office of Clinical Trials and the Office of Contract and Grant Administration, University of California, Los Angeles, CA 90095, USA.

October 19-21, 2001. World Conference on, '2001 Sleep Odyssey: Physiological Basis for Sleep Medicine', organized by World Federation of Sleep Research Societies (WFSRS) and Latin American Sleep Society (LASS), Montevideo, Uruguay (Travel and Accommodation Grant were provided by Sleep Research Society, USA).

October 18-19, 2001. 'Stressor-Induced Alterations in Sleep', organized by Disciplina de Meidicina e Biologia do Sono, Departmento de Psicobiologia, Universidade Federal de Sao Paulo, Brazil.

Sept 12-17, 2000. The Basics of Sleep Behavior. Multi-Site Sleep Training Program for Basic Sleep Research, Organized by the University of California, Los Angeles, at Lake Arrowhead, California, USA.

October 2-8, 1998. Cellular and Molecular Foundations of Sleep Disorders, Sleep Training Workshop organized by the University of California, Los Angeles, at Lake Arrowhead, California, USA.

May 1998, Short Course on Animal Care, organized by the Department of Comparative Medicine, Faculty of Medicine, University of Toronto, Toronto, Canada.

Nov 20, 1997. Workplace Hazardous Materials Information System (WHMIS): 'Train-the-Trainer Program', organized by the Office of the Environmental Health and Safety, University of Toronto, Toronto, Canada.

April 6-10, 1992. Baculovirus Expression Systems, organized by the School of Biological and Molecular Sciences, Oxford Brooks University and Institute of Virology, the University of Oxford at Oxford Brookes University, Headington, Oxford OX3 0BP, England.

NON-ACADEMIC EMPLOYMENT


Worked as a clinical research coordinator at CSI Research Centre, Ontario.

during this time period, my responsibilities include:

• Plan, monitor, and coordinate clinical research studies under the direction of the Principal (PI) and Sub-Investigators (Sub-PI) and collaborates with other clinical research teams to assume responsibility for the overall management and coordination of pharma-sponsored clinical trials focusing on the treatment of insomnia

• Preparation of study documentation (protocols, amendments, case report forms, notes to file, and study reports)

• Collection, processing, and filing of regulatory documents and correspondences, which enables the preparation for audits (by internal and external stakeholders)

• Recruitment of research subjects (e.g. identify potential research subjects, screening (telephone as well as in-person screening), and obtain informed consent

• Coordination of visits schedules as per study protocol requirements as well as tracking of payments

• Execution of all aspects of study visit (e.g. assessment adverse events, monitoring safety, medication, questionnaires, sample collection, including processing and shipment of samples according to study protocol)

• Implementation and coordination of all aspects of data collection and source documentation, as per the sponsor, which conform to the GCP/ICH guidelines

• Coordinated and managed all clinical aspects of assigned studies from study initiation to close-out, ensuring supplies, essential documents are prepared and sufficient resources are in place to perform smooth performance of studies

• Review and maintain study-specific documents including source documentation, CRFs, and other study-related materials

• Monitor clinic conduct to ensure that activities are carried out in compliance with the protocol, SOPs and GCP regulations

• Manage issues with volunteers, staffing, and other study associated query resolution

• Provide leadership and support for study personnel including preparation of study briefings and conducting study initiation meetings as required

• Assist with the recruitment and selection process of Clinical Research Coordinator candidates as well as the training and development of new hire Clinical Research Coordinators and or technical staff

• Participate in training as per the protocols (sponsor/regulatory) requirements, maintain training records, and read all applicable SOPs in a timely manner with appropriate documentation completed

• Collaborates with internal and external stakeholders to develop, manage and evaluate clinical programs considering client needs, service delivery interrelationships, and service potential within a complex environment

• Understands available resources for program/unit and keeps quality in the forefront of all resource utilization decisions; provides feedback and detailed analysis on budget variances, and makes recommendations for corrective action

Worked as a Technician at Biovail CRO for about six months.

During this period, my job responsibilities include:

• Participated along with other clinical trial teams, in maintaining the timeline and target dates for completion of study milestones and using monitoring resources/reports to deliver milestones on time and budget.

• Responsible for the writing and/or reviewing the CRFs (case report forms) adhering to CRF standard operating procedures (SOPs) in compliance with FDA/ICH guidelines.

• Assist in the monitoring of clinical studies along with the CRCs and CRAs thus participated in various activities.

• Worked in collaboration with the CRCs and CRAs and identifies and documents data errors or items requiring clarification on all documents collected for study and initiates data clarification/validation process after researching source documents.

• Assisting the Compliance Specialist in Updating the SOPs